142929-49-5

Basic information

• Product Name: Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI)
• Synonyms: Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI);5-(t-Butyloxycarbonyl-amino)-3-oxapentanoic acid, [2-(Boc-amino)ethoxy]acetic acid, dicyclohexylamine;Boc-O1Pen-OH*DCHA;5-[[(tert-Butoxy)carbonyl]amino]-3-oxapentanoic acid;Boc-5-Amino-3-oxapentanoic acid;(2-Boc-Aminoethoxy)acetic acid;2-(2-((tert-Butoxycarbonyl)aMino)ethoxy)acetic acid;5-(t-Butyloxycarbonyl-aMino)-3-oxapentanoic acid
• CAS NO: 142929-49-5
• Molecular Formula: C₉H₁₇NO₅
• Molecular Weight: 219.23498
• Product Categories: N-BOC
• Mol File: 142929-49-5.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 391.2 °C at 760 mmHg
• Flash Point: 190.4 °C
• Appearance: /
• Density: 1.151 g/cm³
• Vapor Pressure: 3.3E-07mmHg at 25°C
• Refractive Index: 1.462
• Storage Temp.: -20°C
• PKA: 3.44±0.10(Predicted)
• CAS DataBase Reference: Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI)(142929-49-5)
• EPA Substance Registry System: Acetic acid, [2-[[(1,1-dimethylethoxy)carbonyl]amino]ethoxy]- (9CI)(142929-49-5)

Safety Data

• Hazardous Substances Data: 142929-49-5(Hazardous Substances Data)

Usage

Description

t-Boc-N-amido-PEG1-CH2CO2H is a PEG linker containing a terminal carboxylic acid and Boc-protected amino group. The hydrophilic PEG spacer increases solubility in aqueous media. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond. The Boc group can be deprotected under mild acidic conditions to form the free amine.

Chemical Properties

White crystalline powder

Uses

This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains a single PEG unit to help improve solubility

InChI:InChI=1/C9H17NO5/c1-9(2,3)15-8(13)10-4-5-14-6-7(11)12/h4-6H2,1-3H3,(H,10,13)(H,11,12)

Upstream product

• 142929-50-8 ethyl <2-<<(1,1-dimethylethoxy)carbonyl>amino>ethoxy>acetate 
• 26690-80-2 2-(N-tert-butoxycarbonylamino)ethanol 
• 79-08-3 bromoacetic acid 
• 79-11-8 chloroacetic acid 
• 24424-99-5 di-tert-butyl dicarbonate 
• 142929-48-4 1,1-dimethylethyl 3-oxo-4-morpholinecarboxylate 

Downstream Products

• 10366-71-9 2-(2-aminoethoxyl)acetic acid 
• 1351947-21-1 tert-butyl [2-(2-{[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]amino}-2-oxoethoxy)ethyl]carbamate 
• 1351947-13-1 tert-butyl (trans-4-{[2-({5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}oxy)ethyl]carbamoyl}cyclohexyl)carbamate 
• 1351946-97-8 tert-butyl (2-{2-[(3-{5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}propyl)amino]-2-oxoethoxy}ethyl)carbamate 
• 1351946-91-2 tert-butyl {trans-4-[(3-{5-[(2S)-1-methylpyrrolidin-2-yl]pyridin-3-yl}propyl)carbamoyl]cyclohexyl}carbamate 
• 142929-63-3 2-Benzyl-2-(2-tert-butoxycarbonylamino-ethoxy)-3-phenyl-propionic acid ethyl ester 
• 142929-51-9 ethyl α-<2-<<(1,1-dimethylethoxy)carbonyl>amino>ethoxy>benzenepropanoate 

Relevant articles and documents

INHIBITORS OF SOLUBLE ADENYLYL CYCLASE

Provided are 6-amino substituted 2,6-diamino-4-choropyrimidine compounds which are specific inhibitors of soluble adenylyl cyclase. The compounds can be formulated with pharmaceutical carriers and used for reducing cyclic AMP levels. The compositions can

CONJUGATES COMPRISING HYDROXYALKYL STARCH AND A CYTOTOXIC AGENT AND PROCESS FOR THEIR PREPARATION

The present invention relates to a hydroxyalkyl starch conjugate and a method for preparing the same, said hydroxyalkyl starch conjugate comprising a hydroxyalkyl starch derivative and a cytotoxic agent, the cytotoxic agent comprising at least one secondary hydroxyl group, wherein the hydroxyalkyl starch is linked via said secondary hydroxyl group to the cytotoxic agent. The conjugate according to the present invention has a structure according to the following formula HAS′(-L-M)n wherein M is a residue of the cytotoxic agent, L is a linking moiety, HAS′ is the residue of the hydroxyalkyl starch derivative, and n is greater than or equal to 1, and wherein the hydroxyalkyl starch derivative has a mean molecular weight (MW) above the renal threshold.

Concise synthesis of N-protected carboxyalkyl ether amines

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