142929-77-9Relevant academic research and scientific papers
Total synthesis of basiliskamides A and B
Lipomi, Darren J.,Langille, Neil F.,Panek, James S.
, p. 3533 - 3536 (2007/10/03)
(Chemical Equation Presented) The first enantioselective synthesis of the polyketide antibiotics basiliskamides A and B, which exhibit potent in vivo activity against Candida albicans and Aspergillus fumigatus, has been achieved. Serial asymmetric crotylsilane and crotylboronate additions established the C7-C10 stereochemical tetrad. Takai iodoolefination and palladium-mediated cross-coupling were used to install the (Z,E)-vinyl acrylamide. Spectroscopic data is consistent with the assignment of the absolute configurations of the natural products as (7S,8S,9R,10S).
Convergent synthesis of the polyene macrolide (-)-roxaticin
Rychnovsky, Scott D.,Hoye, Rebecca C.
, p. 1753 - 1765 (2007/10/02)
(-)-Roxaticin has been synthesized from polyol tetraacetonide 5, which was prepared by a threefold convergent route. Each of the optically pure building blocks (2, 3, and 4) was prepared using a Noyori asymmetric hydrogenation. Sequential alkylation of di
