73814-98-9

Upstream product

• 111466-55-8 ((2S,3S)-3-(2-(benzyloxy)ethyl)oxiran-2-yl)methanol 
• 19790-60-4 3-Benzyloxypropanal 
• 4799-68-2 3-benzyloxypropan-1-ol 
• 922493-39-8 C₁₆H₂₂O₃ 
• 909803-71-0 (3S,4R)-1-Benzyloxy-4-methyl-hex-5-en-3-ol 
• 909803-77-6 (2S,3S)-5-Benzyloxy-3-hydroxy-2-methyl-pentanal 
• 142929-76-8 (2S,3S)-5-Benzyloxy-3-hydroxy-2-methyl-pentanoic acid ethyl ester 
• 917-64-6 methyl magnesium iodide 
• 73814-97-8 [(2R,3S)-3-(2-Benzyloxy-ethyl)-oxiranyl]-methanol 
• 87205-38-7 (+/-)-(2R,3R)-5-benzyloxy-2,3-epoxy-1-pentanol 
• 95112-81-5 (S)-ethyl 5-benzyloxy-3-hydroxypentanoate 
• 22273-77-4 ((but-3-yn-1-yloxy)methyl)benzene 
• 781642-34-0 (3E,5R,6S)-8-(benzyloxy)-6-hydroxy-5-methyloct-3-enoic acid methyl ester 
• 22273-79-6 5-benzyloxy-2-pentyn-1-ol 

Downstream Products

• 848139-83-3 (2S,3S)-5-Benzyloxy-1-iodo-2-methyl-pentan-3-ol 
• 922493-40-1 (2R,3S)-1-[(tert-butyldiphenylsilyl)oxy]-5-benzyloxy-2-methyl-3-pentanol 
• 1391093-76-7 (2S,3R,4S,5R,6S,7S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-9-(benzyloxy)-5-(tert-butyldimethylsilyloxy)-3-hydroxy-7-methoxy-2,4,6-trimethylnonan-1-one 
• 1391093-75-6 (2R,3S,4S,5S)-7-(benzyloxy)-3-(tert-butyldimethylsilyloxy)-5-methoxy-2,4-dimethylheptanal 
• 1391093-72-3 (2R,3S,4S,5S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-7-(benzyloxy)-3-(tert-butyl-dimethylsilyloxy)-5-methoxy-2,4-dimethylheptan-1-one 
• 1391093-61-0 (2R,3S,4R,5S)-1-((S)-4-benzyl-2-thioxothiazolidin-3-yl)-7-(benzyloxy)-3-hydroxy-5-methoxy-2,4-dimethylheptan-1-one 
• 1391093-69-8 (2R,3S)-5-(benzyloxy)-3-methoxy-2-methylpentan-1-ol 
• 1391093-66-5 ((2R,3S)-5-(benzyloxy)-3-methoxy-2-methylpentyloxy)(tert-butyl)dimethylsilane 
• 1391093-64-3 (2R,3S)-5-(benzyloxy)-1-(tert-butyldimethylsilyloxy)-2-methylpentan-3-ol 
• 794520-82-4 (3S,12R,13R)-15-Benzyloxy-3,13-bis-(tert-butyl-dimethyl-silanyloxy)-1-(4-methoxy-benzyloxy)-12-methyl-pentadecane-6,7,10-trione 
• 794520-81-3 (3R,4R,13S)-1-Benzyloxy-3,13-bis-(tert-butyl-dimethyl-silanyloxy)-15-(4-methoxy-benzyloxy)-4-methyl-pentadec-9-yn-6-one 
• 794520-80-2 [(1R,2S)-3-Benzenesulfonyl-1-(2-benzyloxy-ethyl)-2-methyl-propoxy]-tert-butyl-dimethyl-silane 
• 794520-77-7 (2S,3S)-1-Benzenesulfonyl-5-benzyloxy-2-methyl-pentan-3-ol 
• 794520-79-9 (2S,3R)-1-Benzenesulfonyl-5-benzyloxy-2-methyl-pentan-3-ol 

Relevant academic research and scientific papers

Synthesis and biological activity of mycalolide analogs

Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), a trisoxazole macrolide of marine origin, was stereoselectively synthesized using Roush crotylboration, an Evans aldol reaction, and a Paterson aldol reaction as key steps. The an

Total synthesis of azumamides A and E

A zoom in on azumamides (2): An efficient synthetic route for two of the newly discovered marine natural products, namely azumamides A and E, has been developed (see picture). The present synthesis was followed by determination of the stereochemical structure of the azumamides. (Chemical Equation Presented)

Enantio- and stereocontrolled formation of the bisspiroacetal core of spirolide B

The bisspiroacetal core of spirolide B, a marine natural toxin, was synthesized from triketone 10 via one-step bisspiroacetalization, methylation, and silylation accompanied by isomerization of the C-15 spirocenter. The equilibrium of two isomers under ac

Total synthesis of basiliskamides A and B

(Chemical Equation Presented) The first enantioselective synthesis of the polyketide antibiotics basiliskamides A and B, which exhibit potent in vivo activity against Candida albicans and Aspergillus fumigatus, has been achieved. Serial asymmetric crotylsilane and crotylboronate additions established the C7-C10 stereochemical tetrad. Takai iodoolefination and palladium-mediated cross-coupling were used to install the (Z,E)-vinyl acrylamide. Spectroscopic data is consistent with the assignment of the absolute configurations of the natural products as (7S,8S,9R,10S).

Synthesis and actin-depolymerizing activity of mycalolide analogs

Mycalolide analog 4, consisting only of the side chain of mycalolide B (2), was stereoselectively synthesized and was found to have strong actin-depolymerizing activity.