1429296-06-9

Upstream product

• 1429199-84-7 (7R,8aS)-2-benzyl-7-[(5-cyclopropylpyrazin-2-yl)oxy]octahydropyrrolo[1,2-a]pyrazine 
• 132715-08-3 (6S,8R)-4-benzyl-8-hydroxy-1,4-diazabicyclo<4.3.0>nonane 
• 132714-97-7 (7R,8aS)-2-benzyl-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 132715-17-4 (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate 

Downstream Products

• 1429296-92-3 2-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-oxo-1-[3-(trifluoromethyl)phenyl]ethyl methanesulfonate 
• 1429296-22-9 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-methoxy-2-[3-(trifluoromethyl)phenyl]ethanone 
• 1429296-40-1 1-[(7R,8aS)-7-[(5-cyclopropylpyrazin-2-yl)oxy]hexahydropyrrolo[1,2-a]pyrazin-2(1H)-yl]-2-(methylamino)-2-[3-(trifluoromethyl)phenyl]ethanone 

Relevant academic research and scientific papers

SUBSTITUTED OCTAHYDROPYRROLO[1,2-a]PYRAZINES AS CALCIUM CHANNEL BLOCKERS

The present application relates to: (a) compounds of Formula (I): (I), and salts thereof, wherein Z1, Z2, Z3, Z4, R1, R2, and R3 are as defined in the specification; (b) compositions comprising such compounds and salts; and (c) methods of use of such compounds, salts, and compositions, particularly use as calcium channel inhibitors.