142935-60-2

Basic information

• Product Name: 2-(Benzofuran-5-yl)acetic Acid
• Synonyms: 2-(Benzofuran-5-yl)acetic Acid;Benzofuran-5-yl-Acetic Acid;5-Benzofuranacetic acid
• CAS NO: 142935-60-2
• Molecular Formula: C₁₀H₈O₃
• Molecular Weight: 176.16872
• Mol File: 142935-60-2.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 331.1±17.0 °C(Predicted)
• Appearance: /
• Density: 1.316±0.06 g/cm3(Predicted)
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.22±0.30(Predicted)
• CAS DataBase Reference: 2-(Benzofuran-5-yl)acetic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(Benzofuran-5-yl)acetic Acid(142935-60-2)
• EPA Substance Registry System: 2-(Benzofuran-5-yl)acetic Acid(142935-60-2)

Safety Data

• Hazardous Substances Data: 142935-60-2(Hazardous Substances Data)

Usage

Uses

5-Benzofuranacetic Acid is a reactant used in the preparation of α2-antagonist/5-HT uptake inhibitors as an antidepressant (1).

Upstream product

• 156-38-7 4-hydroxyphenylacetate 
• 142935-51-1 ethyl 2-(benzofuran-5-yl)acetate 
• 142935-50-0 ethyl 2-(4-(2,2-diethoxyethoxy)phenyl)acetate 
• 17138-28-2 (4-hydroxy-phenyl)-acetic acid ethyl ester 
• 1158745-04-0 5-ethynylbenzo[b]furane 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 
• 7252-83-7 1-bromo-2,2-dimethoxyethane 
• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 

Downstream Products

• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 
• 87776-76-9 5-(2-hydroxyethyl)-2,3-dihydrobenzofuran 
• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 

Relevant articles and documents

ADVANTAGEOUS BENZOFURAN COMPOSITIONS FOR MENTAL DISORDERS OR ENHANCEMENT

Pharmaceutically active benzofuran compositions for the treatment of mental disorders or for mental enhancement, including for entactogenic therapy. The present invention also includes benzofuran compounds, compositions, and methods for generally modulating central nervous system activity and treating central nervous system disorders.

Preparation method of acid with different substituent groups

The invention discloses a preparation method of an acid with different substituent groups. A terminal alkyne is lithiated with n-butyllithium, and then reacts with isopropoxyboronic acid pinacol ester, hydrogen chloride is added to achieve quenching, then the obtained reaction product is oxidized by an oxidizing agent, and the oxidized reaction product is separated and purified to obtain the acid.The method of the invention has the advantages of simplicity in operation, one-pot process preparation, no metal catalysis, nontoxic reagents, greenness, environmental friendliness and high atomic utilization rate, and provides a novel and quick way for preparing the acid with different substituent groups; and the obtained acid is an important fine chemical product, and can be widely used in fields of medicines, pesticides, spices and other industries.

ACYLHYDRAZONES AS KINASE MODULATORS

Abstract The invention is directed to acylhydrazones compounds of Formula I: where R1, R2 and A are as defined herein, the use of such compounds as protein tyrosine kinase modulators, particularly inhibitors of c-Met, and the use of such compounds to reduce or inhibit kinase activity of c-Met in a cell or a subject, and modulate c-Met expression in a cell or subject, and the use of such compounds for preventing or treating in a subject a cell proliferative disorder and/or disorders related to c-Met. The present invention is further directed to pharmaceutical compositions comprising the compounds of the present invention and to methods for treating conditions such as cancers and other cell proliferative disorders.