87776-76-9

Basic information

• Product Name: 2,3-Dihydro-5-benzofuranethanol
• Synonyms: 2-(2,3-Dihydrobenzofuran-5-yl)ethanol;2,3-Dihydro-5-benzofuranethanol;5-(2-Hydroxyethyl)-2,3-dihydrobenzofuran;2,3-dihydrobenzofuran-5-ethanol
• CAS NO: 87776-76-9
• Molecular Formula: C₁₀H₁₂O₂
• Molecular Weight: 164.2
• Mol File: 87776-76-9.mol
• Article Data: 19

Chemical Properties

• Boiling Point: 295 °C
• Flash Point: 135 °C
• Appearance: /
• Density: 1.173
• Vapor Pressure: 0.000717mmHg at 25°C
• Refractive Index: 1.579
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,3-Dihydro-5-benzofuranethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3-Dihydro-5-benzofuranethanol(87776-76-9)
• EPA Substance Registry System: 2,3-Dihydro-5-benzofuranethanol(87776-76-9)

Safety Data

• Hazardous Substances Data: 87776-76-9(Hazardous Substances Data)

Usage

Uses

2,3-Dihydro-5-benzofuranethanol is an intermediate in the synthesis of Darifenacin (D193400, HBr); a medication used to treat urinary incontinence. It works by blocking the M3 muscarinic acetylcholine receptor.

InChI:InChI=1/C10H12O2/c11-5-3-8-1-2-10-9(7-8)4-6-12-10/h1-2,7,11H,3-6H2

Upstream product

• 69999-16-2 2,3-dihydrobenzofuran-5-acetic acid 
• 155852-41-8 methyl 2-(2,3-dihydrobenzofuran-5-yl)acetate 
• 943589-92-2 2-(2,3-dihydrobenzofuran-5-yl)acetaldehyde bisulfitic complex 
• 69999-18-4 ethyl 2,3-dihydrobenzofuran-5-ylacetate 
• 496-16-2 2.3-dihydrobenzofuran 
• 79002-49-6 ethyl 2( 2,3-dihydro-1-benzofuran-5-yl)oxoacetate 
• 156-38-7 4-hydroxyphenylacetate 
• 121638-36-6 methyl 2-(benzofuran-5-yl)acetate 
• 142935-60-2 benzofuran-5-yl-acetic acid 

Downstream Products

• 127264-14-6 2,3-dihydro-5-(2-bromoethyl)benzofuran 
• 1423014-75-8 C₂₃H₂₅NO₃ 
• 133099-07-7 (S)-darifenacin hydrobromide 
• 943034-50-2 2-(2,3-dihydrobenzofuran-5-yl)ethylchloride 
• 79679-49-5 2-(2,3-dihidrobenzofuran-5-yl)ethyl tosylate 

Relevant articles and documents

Highly sulphated cellulose: a versatile, reusable and selective desilylating agent for deprotection of alcoholic TBDMS ethers

A mild, efficient and rapid protocol was developed for the deprotection of alcoholic TBDMS ethers using a recyclable, eco-friendly highly sulphated cellulose sulphate acid catalyst in methanol. This acid catalyst selectively cleaves alcoholic TBDMS ethers in bis-TBDMS ethers containing both alcoholic and phenolic TBDMS ether moieties.

Novel preparation method of darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid

The invention relates to a novel preparation method of a darifenacin intermediate 2,3-dihydro-5-benzofuran acetic acid. The method comprises the following steps: by taking 2,3-dihydrobenzofuran as aninitial raw material in the presence of a Lewis acid, carrying out a Friedel-Crafts acylation reaction with ethyl oxalyl monochloride so as to obtain a corresponding acyl compound; hydrolyzing to obtain alpha-ketonic acid sodium salt; reducing carbonyl into methylene by utilizing a Wolff-Kishner-HuangMinlong reaction, and acidizing, thereby obtaining the 2,3-dihydro-5-benzofuran acetic acid. The method disclosed by the invention is simple, convenient and safe, cheap and readily available in reactive raw materials and high in reaction yield and is particularly suitable for industrialized production of the 2,3-dihydro-5-benzofuran acetic acid.

OXAZOLE AND THIAZOLE DERIVATIVES AND THEIR USES

A quaternary ammonium compound of formula (I) having M3 receptor antagonist activity; a composition comprising such a compound; the use of such a compound in therapy (such as asthma or COPD); and a method of treating a patient with such a compound.