142945-22-0

Upstream product

• 83458-91-7 (2E)-6-(benzyloxy)hex-2-en-1-ol 
• 452085-16-4 (S)-Pyrrolidine-1,2-dicarboxylic acid 1-benzyl ester 2-[(R)-4-benzyloxy-1-((S)-2-hydroxy-1-methyl-ethyl)-butyl] ester 
• 75-16-1 methylmagnesium bromide 
• 83458-92-8 ((2R,3R)-3-(3-(benzyloxy)propyl)oxiran-2-yl)methanol 

Downstream Products

• 142945-24-2 (E)-(4R,5R,9S,10R,12R,13S)-16-Benzyloxy-1-(tert-butyl-dimethyl-silanyloxy)-4,10-dimethoxy-12-methoxymethoxy-5,9,13-trimethyl-hexadec-7-en-6-one 
• 142945-23-1 (2R,3R)-6-Benzyloxy-3-methoxy-2-methyl-hexanoic acid methyl ester 
• 452085-30-2 C₅₀H₇₈O₅Si₂ 
• 452085-32-4 ((S)-2-{(2R,5S)-5-[(1R,2S,3R)-3-[(2R,5S)-5-((R)-2-Azido-pentyl)-tetrahydro-furan-2-yl]-2-(4-methoxy-benzyloxy)-1-methyl-butyl]-tetrahydro-furan-2-yl}-propoxy)-tert-butyl-diphenyl-silane 
• 452085-14-2 (4R,5R,6R)-4-(3-Benzyloxy-propyl)-6-[(Z)-(5R,6S)-7-(tert-butyl-diphenyl-silanyloxy)-6-methyl-5-triethylsilanyloxy-hept-1-enyl]-2,2,5-trimethyl-[1,3]dioxane 
• 452085-24-4 (2S,3R,4S,5R)-8-Benzyloxy-2-{(2S,5R)-5-[(S)-2-(tert-butyl-diphenyl-silanyloxy)-1-methyl-ethyl]-tetrahydro-furan-2-yl}-4-methyl-5-triethylsilanyloxy-octan-3-ol 

Relevant academic research and scientific papers

Toward an Asymmetric Synthesis of Bistramide K

The bistramides family has shown antitumoral activity. More specifically bistramide K exhibits lower toxicity than its congeners. In this work, we describe a highly stereoselective and convergent synthesis of two building blocks of the marine metabolite b

A stereocontrolled synthetic route to the C1-C18 subunit of pamamycin-607

The C1-C18 subunit 2 of the 16-membered macrodiolide pamamycin-607 has been synthesized stereoselectively using the Ag2CO3-mediated intramolecular iodoetherification for the two cis-2,5-disubstituted tetrahydrofurans, crotylation and cuprate epoxide opening for the hydroxyl and methyl substituents.

Synthetic Studies towards Halichondramides, and Related Novel tris-Oxazole Containing Macrolides from Marine Organisms. A Concise Route to the Keto-triol Formyl Enamine Moiety.

A synthesis of the keto-triol formyl enamine moiety (3) in the marine metabolite halichondramide (1) is described.The synthesis features judicious application of the Evans chiral aldol protocol in combination with the controlled ring opening of chiral α-e