1429498-29-2

Upstream product

• 1429498-34-9 3-(1-methyl-1H-benzimidazol-2-yl)benzaldehyde 
• 105-53-3 diethyl malonate 
• 95-54-5 1,2-diamino-benzene 
• 134469-07-1 Benzimidazol-2-thiol 
• 54624-57-6 2-bromo-1H-1,3-benzodiazole 
• 49572-60-3 2-bromo-1-methyl-1H-benzo[d]imidazole 

Relevant academic research and scientific papers

Design and synthesis of benzimidazole-linked meta-substituted benzylidenes/benzyls as biologically significant new chemical entities

meta-Linked thiazolidinedione (TZD)-and diethyl malonate (DEM)-based benzylidenes and methyl acetoacetate (MAA)-based benzyl moieties linked to the 2-position of N-methyl benzimidazole were synthesized. TZD-and DEM-based compounds were synthesized by condensation of 2,4-thiazolidinedone and DEM respectively with the corresponding 3-substituted benzaldehyde, whereas MAA-based compounds were obtained by halogen displacement with the corresponding 3-substituted phenol. These new chemical entities were designed to provide a balanced agonism at the peroxisome proliferator activated receptor alpha/gamma (PPARα/γ) in the management of type 2 diabetes: a move from glitazones to selective PPARγ modulators (SPPARγMs). Supplemental materials are available for this article. Go to the publisher's online edition of Synthetic Communications to view the free supplemental file.