1429887-51-3

Basic information

• Product Name: 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole
• Synonyms: 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole
• CAS NO: 1429887-51-3
• Molecular Weight: 355.458
• Mol File: 1429887-51-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole(1429887-51-3)
• EPA Substance Registry System: 3-allyl-5-methoxy-2-methyl-1-[(4-methylphenyl)sulfonyl]-1H-indole(1429887-51-3)

Safety Data

• Hazardous Substances Data: 1429887-51-3(Hazardous Substances Data)

Upstream product

• 1314595-90-8 N-(2-iodo-4-methoxylphenyl)-4-methylbenzenesulfonamide 
• 69643-52-3 hex-5-en-2-ynyl bromide 

Downstream Products

• 24438-50-4 3-allyl-5-methoxy-2-methyl-1-(4-chlorobenzoyl)indole 
• 24438-51-5 zhucan-7-15 
• 24438-49-1 <1-(4-chlorobenzoyl)-2-methyl-5-methoxyindol-3-yl>acetaldehyde 
• 53-86-1 [1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetic acid 

Relevant articles and documents

Coupling and cyclization of O-iodoanilines and propargylic bromides via allenes: An efficient entry to indomethacin

A sequential allene synthesis and cyclization has been realized in a one-pot manner. A Pd(0)-catalyzed one-pot reaction of N-Ts or -Ms 2-iodoanilines and propargylic bromides afforded indoles with pharmaceutical importance highly efficiently with diversity via sequential carbon-carbon bond coupling forming allenes and azapalladation. With this newly established methodology, an efficient approach to indomethacin, an anti-inflammatory drug (NSAID), has been accomplished.