143004-34-6

Basic information

• Product Name: Butanoic acid, 4-chloro-3-(phenylmethoxy)-, ethyl ester, (R)-
• CAS NO: 143004-34-6
• Molecular Formula: C13H17ClO3
• Molecular Weight: 256.729
• Mol File: 143004-34-6.mol

Chemical Properties

• CAS DataBase Reference: Butanoic acid, 4-chloro-3-(phenylmethoxy)-, ethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Butanoic acid, 4-chloro-3-(phenylmethoxy)-, ethyl ester, (R)-(143004-34-6)
• EPA Substance Registry System: Butanoic acid, 4-chloro-3-(phenylmethoxy)-, ethyl ester, (R)-(143004-34-6)

Safety Data

• Hazardous Substances Data: 143004-34-6(Hazardous Substances Data)

Upstream product

• 10488-69-4 ethyl (L)-4-chloro-3-hydroxybutyrate 
• 100-39-0 benzyl bromide 

Downstream Products

• 900513-88-4 (1R,2R)-2-[(R)-3-(benzyloxy)pyrrolidin-1-yl]cyclohexanol 
• 1360871-01-7 (R)-4-(benzyloxy)-1-[(1R,2R)-2-(tert-butyldiphenylsiloxy)cyclohexyl]pyrrolidin-2-one 
• 1360871-05-1 (R)-4-(benzyloxy)-1-[(1S,2S)-2-(tert-butyldiphenylsiloxy)cyclohexyl]pyrrolidin-2-one 
• 1360870-99-0 (R)-4-(benzyloxy)-1-[(1R,2R)-2-(triethylsiloxy)cyclohexyl]pyrrolidin-2-one 
• 1360871-04-0 (R)-4-(benzyloxy)-1-[(1S,2S)-2-(triethylsiloxy)cyclohexyl]pyrrolidin-2-one 
• 1360870-97-8 (R)-4-(benzyloxy)-1-[(1R,2R)-2-(tert-butyldimethylsiloxy)cyclohexyl]pyrrolidin-2-one 
• 1360871-03-9 (R)-4-(benzyloxy)-1-[(1S,2S)-2-(tert-butyldimethylsiloxy)cyclohexyl]pyrrolidin-2-one 

Relevant articles and documents

New procedure for the preparation of (1 R,2 R)-2-[(R)-3-(benzyloxy)pyr- rolidin-1-yl]cyclohexanol

A novel route to an intermediate of vernakalant, (1R,2R)-2-[(R)-3- (benzyloxy)pyrrolidin-1-yl]cyclohexanol from ethyl (R)-4-chloro-3- hydroxybutanoate is described. It was found that the key intermediate (R)-4-(benzyloxy)-1-[(1R,2R)-2-(tert-butyldimethylsiloxy)cyclohexyl] pyrrolidin-2-one could be isolated with high dia-stereomeric excess (up to 99% de) from its isomer by column chromatography alone, without further chemical resolution. Georg Thieme Verlag Stuttgart. New York.