1430104-92-9Relevant academic research and scientific papers
Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists
Yang, Christine,Shen, Hong C.,Wu, Zhicai,Chu, Hong D.,Cox, Jason M.,Balsells, Jaume,Crespo, Alejandro,Brown, Patricia,Zamlynny, Beata,Wiltsie, Judyann,Clemas, Joseph,Gibson, Jack,Contino, Lisa,Lisnock, Jeanmarie,Zhou, Gaochao,Garcia-Calvo, Margarita,Bateman, Tom,Xu, Ling,Tong, Xinchun,Crook, Martin,Sinclair, Peter
, p. 4388 - 4392 (2013)
Novel oxazolidinedione analogs were discovered as potent and selective mineralocorticoid receptor (MR) antagonists. Structure-activity relationship (SAR) studies were focused on improving the potency and microsomal stability. Selected compounds demonstrat
MINERALOCORTICOID RECEPTOR ANTAGONISTS
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, (2013/04/25)
The present invention is directed to compounds of the Formula (I) as well as pharmaceutically acceptable salts thereof, that are potentially useful for treating aldosterone-mediated diseases. The invention furthermore relates to processes for preparing compounds of the Formula (I), to their possible use in the treatment of the above mentioned diseases and for preparing pharmaceuticals for this purpose, and to pharmaceutical compositions which comprise compounds of the Formula (I).
