Discovery of novel oxazolidinedione derivatives as potent and selective mineralocorticoid receptor antagonists

DOI: 10.1016/j.bmcl.2013.05.077

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 4388 - 4392 (2013)

Update date:2022-08-05

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Authors:

Yang, Christine

Shen, Hong C.

Wu, Zhicai

Chu, Hong D.

Cox, Jason M.

Balsells, Jaume

Crespo, Alejandro

Brown, Patricia

Zamlynny, Beata

Wiltsie, Judyann

Clemas, Joseph

Gibson, Jack

Contino, Lisa

Lisnock, Jeanmarie

Zhou, Gaochao

Garcia-Calvo, Margarita

Bateman, Tom

Xu, Ling

Tong, Xinchun

Crook, Martin

Sinclair, Peter

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Article abstract of DOI:10.1016/j.bmcl.2013.05.077

Novel oxazolidinedione analogs were discovered as potent and selective mineralocorticoid receptor (MR) antagonists. Structure-activity relationship (SAR) studies were focused on improving the potency and microsomal stability. Selected compounds demonstrat

Full text of DOI:10.1016/j.bmcl.2013.05.077

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