1430210-54-0

Basic information

• Product Name: 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole
• Synonyms: 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole
• CAS NO: 1430210-54-0
• Molecular Weight: 558.677
• Mol File: 1430210-54-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole(1430210-54-0)
• EPA Substance Registry System: 2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole(1430210-54-0)

Safety Data

• Hazardous Substances Data: 1430210-54-0(Hazardous Substances Data)

Upstream product

• 1239963-73-5 1-amino-3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one hydrochloride 
• 106-41-2 4-bromo-phenol 
• 1239963-74-6 5-(2-(3,4-dimethoxyphenyl)propan-2-yl)-1-(4-fluorophenyl)-1H-imidazole-2-thiol 
• 1430211-86-1 3-(3,4-dimethoxyphenyl)-3-methylbutan-2-ol 
• 717105-57-2 2-(3,4-dimethoxyphenyl)-2-methylpropanal 
• 23023-16-7 2‐(3,4‐dimethoxyphenyl)‐2‐methylpropionitrile 
• 10041-02-8 p-imidazo-1-ylphenol 
• 1430211-87-2 1-bromo-3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one 
• 4461-99-8 3-(3,4-dimethoxyphenyl)-3-methylbutan-2-one 

Downstream Products

• 1430211-32-7 4-(2-(2-((2-(4-(1H-imidazol-1-yl)phenoxy)ethyl)thio)-1-(4-fluorophenyl)-1H-imidazol-5-yl)propan-2-yl)benzene-1,2-diol 

Relevant articles and documents

Practical and Efficient Synthesis of 2-Thio-imidazole Derivative - ZY12201: A Potent TGR5 Agonist

Early scalable process development for the synthesis of ZY12201, a novel TGR5 receptor agonist, as a potential clinical candidate is described. A practical, efficient, and scalable synthetic route provided ZY12201 in seven steps and 32% overall yield. The

2-THIO-IMIDAZOLE DERIVATIVES AS TGR5 MODULATORS

The present invention relates to compounds of the general Formula I their pharmaceutically acceptable salts, pharmaceutically acceptable solvates, enantiomers, diastereomers, prodrugs, their N-oxide, metabolites, polymorphs, use of these compounds in medicine for treating diabetes (TGR5 modulators) and the intermediates involved in their preparation.