143034-54-2

Upstream product

• 35452-04-1 N,N-dimethylbenzamide dimethyl acetal 
• 2533-68-8 trichloroacetamidine 
• 2397-26-4 N,N-dimethyl(chlorophenylmethylene)ammonium chloride 
• 611-74-5 N,N-dimethylbenzamide 

Downstream Products

• 143034-51-9 2-(trichloromethyl)-4-phenylpyrimidine-5-carboxaldehyde 
• 143034-50-8 methyl 2-(trichloromethyl)-4,6-diphenylpyrimidine-5-carboxylate 
• 143034-48-4 dimethyl 2-(trichloromethyl)-6-phenylpyrimidine-4,5-dicarboxylate 
• 143034-49-5 ethyl 2-(trichloromethyl)-4-phenylpyrimidine-5-carboxylate 
• 100964-66-7 4-phenyl-2-trichloromethylquinazoline 

Relevant academic research and scientific papers

Syntheses of 4-substituted 2-(trichloromethyl)quinazolines under mild conditions by benzyne [4+2] cycloaddition

An experimentally simple and convenient synthesis of 4-susbstituted 2-(trichloromethyl)quinazolines by cycloaddition of benzyne with 2-(trichloromethyl)-1,3-diazabutadienes was developed. The 2-(trichloromethyl)-1,3-diazabutadienes (R1 = H and Me) were prepared from trichloroacetamidine and the appropriate N,N-dimethylamide dimethyl acetal or from trichloroacetamidine and a Vilsmeier-Haack reagent containing an aryl group.

Synthesis of Pyrimidines from 2-Trichloromethyl-4-dimethylamino-1,3-diaza-1,3-butadienes and Electron Deficient Acetylenes

2-Trichloromethyl-4-dimethylamino-1,3-diaza-1,3-butadienes(3), prepared from trichloroacetamidine(1) and amide acetals 2, readily react with electron deficient acetylenes 4 to give 2-trichloromethylpyrimidines 5.