100964-66-7Relevant academic research and scientific papers
Syntheses of 4-substituted 2-(trichloromethyl)quinazolines under mild conditions by benzyne [4+2] cycloaddition
Lechuga-Eduardo, Harim,Olivo, Horacio F.,Romero-Ortega, Moises
, p. 5910 - 5913 (2015/03/30)
An experimentally simple and convenient synthesis of 4-susbstituted 2-(trichloromethyl)quinazolines by cycloaddition of benzyne with 2-(trichloromethyl)-1,3-diazabutadienes was developed. The 2-(trichloromethyl)-1,3-diazabutadienes (R1 = H and Me) were prepared from trichloroacetamidine and the appropriate N,N-dimethylamide dimethyl acetal or from trichloroacetamidine and a Vilsmeier-Haack reagent containing an aryl group.
Synthesis and antiplasmodial activity of new 4-aryl-2-trichloromethylquinazolines
Verhaeghe, Pierre,Azas, Nadine,Gasquet, Monique,Hutter, Sebastien,Ducros, Christophe,Laget, Michele,Rault, Sylvain,Rathelot, Pascal,Vanelle, Patrice
, p. 396 - 401 (2008/12/21)
A series of original 4-aryl-substituted 2-trichloromethylquinazoline derivatives was synthesized using a microwave-assisted Suzuki-Miyaura cross-coupling approach. Antiplasmodial activity was evaluated on both chloroquino-resistant and -sensitive Plasmodi
SYNTHESIS OF QUINAZOLINES
Bergman, Jan,Brynolf, Anna,Elman, Bjoern,Vuorinen, Eino
, p. 3697 - 3706 (2007/10/02)
Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate (10), which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates).The intermediate (10) and aldehy
