143060-04-2

Upstream product

• 42856-52-0 1-benzyl-3,4-dimethyl-2,5-pyrrolidinedione 
• 142955-03-1 (3R,4R)-1-Benzyl-1-((1S,2R)-2-hydroxy-1-methyl-2-phenyl-ethyl)-3,4-dimethyl-pyrrolidinium; bromide 
• 142955-02-0 (1R,2S)-2-((3R,4R)-3,4-Dimethyl-pyrrolidin-1-yl)-1-phenyl-propan-1-ol 
• 137314-77-3 2-Iodo-1-((2S,4S,5R)-4-methyl-5-phenyl-2-vinyl-oxazolidin-3-yl)-propan-1-one 
• 137314-76-2 2-Chloro-1-((2S,4S,5R)-4-methyl-5-phenyl-2-vinyl-oxazolidin-3-yl)-propan-1-one 
• 137314-91-1 (2R,3S,6R,7R,7aS)-3,6,7-Trimethyl-2-phenyl-tetrahydro-pyrrolo[2,1-b]oxazol-5-one 
• 100-39-0 benzyl bromide 

Relevant academic research and scientific papers

Asymmetric desymmetrization of meso-pyrrolidine derivatives by enantiotopic selective C-H hydroxylation using (salen)manganese(III) complexes

Chiral (salen)manganese(III) complexes 1 catalyzed the asymmetric desymmetrization of N-protected meso-pyrrolidine derivatives 3, 6-8, 15 and 18 by enantiotopic selective C-H oxidation in the presence of terminal oxidant iodosylbenzene. The oxidation occurred chemoselectively at the carbon α to the nitrogen atom to afford optically active hydroxypyrrolidine derivatives 9, 11, 13, 16, 19 and 21 that were further oxidized to chiral lactams with Jones reagent. The N-protecting groups of the meso-pyrrolidine derivatives have notable effect on the enantioselectivity.

Stereoselective Radical-Mediated Cyclization of Norephedrine Derived α-Iodoamides: Synthesis of Enantiopure Pyrrolidines and Transition State Modelling

Radical-mediated cyclization of norephedrine derived α-iodoamides 1 was found to be highly stereoselective ( 97:3) favouring diastereoisomer 2.Bicyclic lactams 2 were transformed in high yields into enantiomerically pure pyrrolidines 10.Transition stat