143062-84-4

Usage

Uses

Used in Pharmaceutical Research:
(1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE is used as a key intermediate in the synthesis of pharmaceutical compounds for [application reason]. Its unique structure allows for the creation of new drug candidates with potential therapeutic benefits.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE is used as a chiral building block for [application reason]. Its incorporation into more complex molecules can lead to the development of novel drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
(1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE is employed as a versatile reagent in organic synthesis for [application reason]. Its fluorine-substituted cyclopropylamine core can be a valuable component in the construction of a wide range of organic compounds, including potential pharmaceutical agents.
Used in Drug Discovery:
In drug discovery, (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE is used as a starting material for [application reason]. Its unique stereochemistry and reactivity make it a promising candidate for the development of new therapeutic agents, particularly in the context of targeted drug delivery and personalized medicine.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 142977-51-3 (4R,5S)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5-diphenyl-oxazolidin-2-one 
• 156481-81-1 (R)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5,5-triphenyl-oxazolidin-2-one 
• 142977-41-1 benzyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 142977-39-7 benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 
• 127199-16-0 tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate 
• 598-67-4 1,1,2-tribromo-2-fluoroethane 
• 108-59-8 malonic acid dimethyl ester 

Downstream Products

• 142977-48-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1R,2S)-2-fluorocyclopropylcarbamate 
• 143059-80-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1S,2R)-2-fluorocyclopropylcarbamate 
• 141042-21-9 (-)-cis-2-fluorocyclopropylamine hydrochloride 
• 142977-49-9 N-((1R,2S)-2-Fluoro-cyclopropyl)-3,5-dinitro-benzamide 

Relevant academic research and scientific papers

Sitafloxacin three membered ring intermediate preparation method

The invention discloses a preparation method for a three-membered ring intermediate of sitafloxacin hydrate. The preparation method comprises the following steps: dimethyl malonate and 1,1,2-tribromo-2-fluoroethane react to synthesize a solid A, the solid A is subjected to debromination to prepare an oily liquid B, the oily liquid B is subjected to branched chain removal to prepare a solid C, the solid C is hydrolyzed to prepare a solid D, the solid D is subjected to chiral resolution with L-leucinamide and reduced to prepare a solid F, the solid F is introduced to an amino group and combined with p-toluenesulfonic acid to prepare the three-membered ring intermediate of sitafloxacin hydrate. The preparation method has fewer steps for preparing the three-membered ring intermediate of sitafloxacin hydrate, unnecessary isomer is separated by one step with the chiral resolution method, the product yield and purity are higher, and scale production is easier.

Stereoselective synthesis of cis -2-fluorocyclopropanecarboxylic acid

A rhodium-catalyzed cyclopropanation of 1-fluoro-1-(phenylsulfonyl)ethylene and diazo esters is described as an effective method for the stereoselective synthesis of cis-2-fluorocyclopropanecarboxylic acid. This process provides an example of the cyclopro

Synthesis of cis-2-fluorocyclopropylamine by stereoselective cyclopropanation under phase-transfer conditions

cis-2-Fluorocyclopropylamine is stereoselectively synthesized by cyclopropanation of 3-aryl-2-vinyl-3-(methoxy)isoin-dol-1-one by treating dibromofluoromethane with saturated aqueous KOH solution in the presence of 18-crown-6 in dichloromethane, followed by removal of a bromine atom of the formed bromofluorocyclopropane derivative with Raney Ni, and successive three steps-deprotection procedures for generating an amino group on the cyclopropane ring.

Synthetic studies on the key component of the new generation of quinolonecarboxylic acid, DU-6859. 1. Synthesis of (1R,2S)-2-fluorocyclopropylamine by the use of optical resolution

The title synthesis was achieved by employing highly cis-selective cyclopropanation of N-benzyl-N-vinylcarbamates with zinc-monofluorocarbenoid, deprotection of the formed N-benzyl-N-(cis-2-fluorocyclopropyl)carbamates, and optical resolution of the resul

Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine

The title synthesis was achieved by featuring diastereoface-selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone and its related compounds, the chiral conformationally rigid N-vinylcarbamates, with zinc-monofluorocarbenoid, followed

Synthesis and optical resolution of dl-cis-2-fluorocyclopropylamine, the key component of the new generation of quinolonecarboxylic acid, DU-6859

The title synthesis was accomplished by featuring highly cis-selective cyclopropanation of an N-vinylcarbamate with zinc-monofluorocarbenoid followed by deprotection of the formed N-(cis-2-fluorocyclopropyl)carbamate. Optical resolution of dl-cis-2-fluoro

Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine, the Key Intermediate of the New Generation of Quinolonecarboxylic Acid, DU-6859

The title synthesis was achieved by featuring diastereoface selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone, the chiral and conformationally rigid N-vinylcarbamate, with zincmonofluorocarbenoid followed by hydrogenolysis of form