143062-84-4

Basic information

• Product Name: (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE
• Synonyms: (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE;(1R,2S)-2-Fluorocyclopropanamine 4-methylbenzenesulfonate;(1R,2S)-2-Fluorocyclopropylamine tosylate;Cyclopropanamine, 2-fluoro-,(1R,2S)-,4-methylbenzenesulfonate;(1R,2S)-4-Methylbenzenesulfonate-2-fluoro-CyclopropanaMine;CyclopropanaMine, 2-fluoro-, (1R,2S)-, 4-Methylbenzenesulfonate (1:1);(2-fluorocyclopropyl)aMino 4-Methylbenzene-1-sulfonate;(1R,2S)-2-Fluorocyclopropan-1-amine 4-methylbenzenesulphonate, (1R,2S)-2-Fluorocyclopropan-1-amine tosylate
• CAS NO: 143062-84-4
• Molecular Formula: C₃H₆FN*C₇H₈O₃S
• Molecular Weight: 247.29
• EINECS: 1308068-626-2
• Mol File: 143062-84-4.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 418.2 °C at 760 mmHg
• Flash Point: 206.7 °C
• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE(143062-84-4)
• EPA Substance Registry System: (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE(143062-84-4)

Safety Data

• Hazardous Substances Data: 143062-84-4(Hazardous Substances Data)

Usage

General Description

(1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE is a chemical compound that consists of a fluorine-substituted cyclopropylamine molecule, which is further modified with a tosylate group. It is a chiral compound, with a stereochemical configuration of (1R,2S). (1R,2S)-FLUOROCYCLOPROPYLAMINE TOSYLATE has potential applications in medicinal and pharmaceutical research, as well as in the synthesis of organic compounds. It can be used as a building block in the creation of other more complex molecules, and its unique structure makes it a valuable tool for drug discovery and development. It is important to handle and use this compound with care and in accordance with appropriate safety precautions due to its potential reactivity and toxicity.

Upstream product

• 104-15-4 toluene-4-sulfonic acid 
• 156481-81-1 (R)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5,5-triphenyl-oxazolidin-2-one 
• 142977-39-7 benzyl N-<(1R*,2S*)-2-fluorocyclopropyl>-N-(1-phenylethyl)carbamate 
• 142977-41-1 benzyl N-diphenylmethyl-N-<(1R*,2S*)-2-fluorocyclopropyl>carbamate 
• 598-67-4 1,1,2-tribromo-2-fluoroethane 
• 108-59-8 malonic acid dimethyl ester 
• 127199-16-0 tert-butyl N-<(1R,2S)-2-fluorocyclopropyl>carbamate 
• 142977-51-3 (4R,5S)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5-diphenyl-oxazolidin-2-one 

Downstream Products

• 141042-21-9 (-)-cis-2-fluorocyclopropylamine hydrochloride 
• 142977-49-9 N-((1R,2S)-2-Fluoro-cyclopropyl)-3,5-dinitro-benzamide 
• 142977-48-8 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1R,2S)-2-fluorocyclopropylcarbamate 
• 143059-80-7 (1R,2S,5R)-5-methyl-2-(1-methylethyl)cyclohexyl N-(1S,2R)-2-fluorocyclopropylcarbamate 

Relevant articles and documents

Sitafloxacin three membered ring intermediate preparation method

The invention discloses a preparation method for a three-membered ring intermediate of sitafloxacin hydrate. The preparation method comprises the following steps: dimethyl malonate and 1,1,2-tribromo-2-fluoroethane react to synthesize a solid A, the solid A is subjected to debromination to prepare an oily liquid B, the oily liquid B is subjected to branched chain removal to prepare a solid C, the solid C is hydrolyzed to prepare a solid D, the solid D is subjected to chiral resolution with L-leucinamide and reduced to prepare a solid F, the solid F is introduced to an amino group and combined with p-toluenesulfonic acid to prepare the three-membered ring intermediate of sitafloxacin hydrate. The preparation method has fewer steps for preparing the three-membered ring intermediate of sitafloxacin hydrate, unnecessary isomer is separated by one step with the chiral resolution method, the product yield and purity are higher, and scale production is easier.

Synthesis of cis-2-fluorocyclopropylamine by stereoselective cyclopropanation under phase-transfer conditions

cis-2-Fluorocyclopropylamine is stereoselectively synthesized by cyclopropanation of 3-aryl-2-vinyl-3-(methoxy)isoin-dol-1-one by treating dibromofluoromethane with saturated aqueous KOH solution in the presence of 18-crown-6 in dichloromethane, followed by removal of a bromine atom of the formed bromofluorocyclopropane derivative with Raney Ni, and successive three steps-deprotection procedures for generating an amino group on the cyclopropane ring.

Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine

The title synthesis was achieved by featuring diastereoface-selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone and its related compounds, the chiral conformationally rigid N-vinylcarbamates, with zinc-monofluorocarbenoid, followed