1430748-22-3Relevant academic research and scientific papers
Synthesis, Characterization, Cytotoxicity, and Antibacterial Properties of trans-γ-Halo-δ-lactones
Kamizela, Angelika,Gawdzik, Barbara,Urbaniak, Mariusz,Lechowicz, ?ukasz,Bia?ońska, Agata,Gonciarz, Weronika,Chmiela, Magdalena
, p. 543 - 550 (2018)
A new four-step pathway for the synthesis of γ-halo-δ-lactones is described from simple, commercially available substrates: aryl bromides and 3-methyl crotonaldehyde. The halogenolactonization reaction of β,δ-substituted, γ,δ-unsaturated carboxylic acid 4
Enantiospecific intramolecular heck reactions of secondary benzylic ethers
Harris, Michael R.,Konev, Mikhail O.,Jarvo, Elizabeth R.
supporting information, p. 7825 - 7828 (2014/06/23)
Enantioenriched methylenecyclopentanes are synthesized by stereospecific, nickel-catalyzed Heck cyclizations of secondary benzylic ethers. The reaction proceeds in high yield and enantiospecificity for benzylic ethers of both π-extended and simple arenes. Ethers with pendant 1,2-disubstituted olefins form trisubstituted olefins with control of both absolute configuration and alkene geometry. Diastereoselective synthesis of a polycyclic furan is demonstrated.
Ruthenium-catalyzed remote electronic activation of aromatic C-F bonds
Watson, Andrew J. A.,Atkinson, Benjamin N.,Maxwell, Aoife C.,Williams, Jonathan M. J.
supporting information, p. 734 - 740 (2013/04/10)
The tandem isomerization and nucleophilic aromatic substitution of allylic fluoro-substituted benzylic alcohols is described for the first time. In the presence of the ruthenium complex Ru(PPh3)3(CO)(H) 2, 1-(4-fluorophenyl)prop-2-en-1-ol is converted into the corresponding para-amino ketone or para-phenolic substituted ketone. Copyright
