92236-75-4Relevant academic research and scientific papers
Enantiospecific intramolecular heck reactions of secondary benzylic ethers
Harris, Michael R.,Konev, Mikhail O.,Jarvo, Elizabeth R.
, p. 7825 - 7828 (2014/06/23)
Enantioenriched methylenecyclopentanes are synthesized by stereospecific, nickel-catalyzed Heck cyclizations of secondary benzylic ethers. The reaction proceeds in high yield and enantiospecificity for benzylic ethers of both π-extended and simple arenes. Ethers with pendant 1,2-disubstituted olefins form trisubstituted olefins with control of both absolute configuration and alkene geometry. Diastereoselective synthesis of a polycyclic furan is demonstrated.
