14309-33-2

Upstream product

• 14371-10-9 (E)-3-phenylpropenal 
• 480-96-6 benzofurazan oxide 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 57859-60-6 ethyl 3-phenylquinoxaline-2-carboxylate 1,4-di-N-oxide 
• 6935-29-1 quinoxaline-N-oxide 
• 71-43-2 benzene 
• 73230-63-4 ethyl 3-phenylquinoxaline-2-carboxylate 4-N-oxide 
• 591-50-4 iodobenzene 
• 73210-44-3 2-phenylquinoxaline-3-carboxylic acid 1-oxide 

Downstream Products

• 14519-64-3 1a-phenyl-1aH-oxazirino[2,3-a]quinoxaline 

Relevant academic research and scientific papers

Palladium-catalyzed C-H functionalization of pyridine N-oxides: Highly selective alkenylation and direct arylation with unactivated arenes

Two catalytic protocols of the oxidative C-C bond formation have been developed on the basis of the C-H bond activation of pyridine N-oxides. Pd-catalyzed alkenylation of the N-oxides proceeds with excellent regio-, stereo-, and chemoselectivity, and the

Use of N-oxide compounds in coupling reactions

Metal-catalyzed coupling process comprising reacting a compound of general formula 1 with a compound A-X, to obtain a compound of general formula 2, which may further be converted to a compound of general formula 3

Palladium-catalyzed cross-coupling reactions of diazine N-oxides with aryl chlorides, bromides, and iodides

New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield

Formation of Quinoxaline Monoxides from Reaction of Benzofurazan Oxide with Enones and 13C NMR Correlations of Quinoxaline N-Oxides

Benzofuran oxide (1) reacts with a variety of enones and amines to give quinoxaline monoxides.The nature of the amine determines the regiochemistry of the product: secondary amines give a type 4 product and primary amines give a type 5 product.Reaction of 1, cinnamaldehyde, and morpholine gave both 4a and 8a.The regiochemistry of these N-oxide products is discussed in terms of intermediate 11.Principal limitations of these reactions for synthesis are the low yields and the lack of universality for enones as substrates. 13C NMR correlations for quinoxaline monoxides and dioxides are presented.