73230-63-4Relevant academic research and scientific papers
Unexpected reduction of ethyl 3-phenylquinoxaline-2-carboxylate 1,4-Di-N-oxide derivatives by amines
Lima, Lidia M.,Vicente, Esther,Solano, Beatriz,Perez-Silanes, Silvia,Aldana, Ignacio,Monge, Antonio
, p. 78 - 85 (2008)
The unexpected tendency of amines and functionalized hydrazines to reduce ethyl 3-phenylquinoxaline-2-carboxylate 1,4-di-N-oxide (1) to afford a quinoxaline 1c and mono-oxide quinoxalines 1a and 1b is described. The experimental conditions were standardiz
Formation of Quinoxaline Monoxides from Reaction of Benzofurazan Oxide with Enones and 13C NMR Correlations of Quinoxaline N-Oxides
Kluge, Arthur F.,Maddox, Michael L.,Lewis, Graham S.
, p. 1909 - 1914 (2007/10/02)
Benzofuran oxide (1) reacts with a variety of enones and amines to give quinoxaline monoxides.The nature of the amine determines the regiochemistry of the product: secondary amines give a type 4 product and primary amines give a type 5 product.Reaction of 1, cinnamaldehyde, and morpholine gave both 4a and 8a.The regiochemistry of these N-oxide products is discussed in terms of intermediate 11.Principal limitations of these reactions for synthesis are the low yields and the lack of universality for enones as substrates. 13C NMR correlations for quinoxaline monoxides and dioxides are presented.
