14310-35-1Relevant academic research and scientific papers
Nickel-Catalyzed Regiodivergent Reductive Hydroarylation of Styrenes
Xue, Yuhang,Chen, Jian,Song, Peihong,He, Yuli,Zhu, Shaolin
supporting information, p. 1647 - 1651 (2021/07/02)
We report a ligand-controlled nickel-catalyzed reductive hydroarylation of styrenes with predictable and controllable regioselectivity. With a diamine ligand, the reaction produces selective linear hydroarylation products. Alternatively, with a chiral PyrOx ligand, branch-selective enantioenriched 1,1-diarylalkane products are obtained. Preliminary mechanistic results are consistent with a reductive Heck process.
Chemoselective Hydrogenation of Alkynes to (Z) -Alkenes Using an Air-Stable Base Metal Catalyst
Zubar, Viktoriia,Sklyaruk, Jan,Brzozowska, Aleksandra,Rueping, Magnus
supporting information, p. 5423 - 5428 (2020/07/24)
A highly selective hydrogenation of alkynes using an air-stable and readily available manganese catalyst has been achieved. The reaction proceeds under mild reaction conditions and tolerates various functional groups, resulting in (Z)-alkenes and allylic alcohols in high yields. Mechanistic experiments suggest that the reaction proceeds via a bifunctional activation involving metal-ligand cooperativity.
Nickel-catalyzed C-N bond activation: Activated primary amines as alkylating reagents in reductive cross-coupling
Yue, Huifeng,Zhu, Chen,Shen, Li,Geng, Qiuyang,Hock, Katharina J.,Yuan, Tingting,Cavallo, Luigi,Rueping, Magnus
, p. 4430 - 4435 (2019/04/29)
Nickel-catalyzed reductive cross coupling of activated primary amines with aryl halides under mild reaction conditions has been achieved for the first time. Due to the avoidance of stoichiometric organometallic reagents and external bases, the scope regarding both coupling partners is broad. Thus, a wide range of substrates, natural products and drugs with diverse functional groups are tolerated. Moreover, experimental mechanistic investigations and density functional theory (DFT) calculations in combination with wavefunction analysis have been performed to understand the catalytic cycle in more detail.
Copper-Catalyzed Radical Reductive Arylation of Styrenes with Aryl Iodides Mediated by Zinc in Water
Zhou, Feng,Hu, Xiaoyun,Zhang, Wanying,Li, Chao-Jun
, p. 7416 - 7422 (2018/05/14)
A copper/aniline catalyst system enables the radical arylation of styrenes using aryl iodides mediated by zinc in water. This transformation provides an efficient synthetic methodology for the convenient synthesis of diarylethane.
