143100-05-4Relevant academic research and scientific papers
New approaches to the asymmetric synthesis of α-methylphenylalanine
Cativiela,Diaz-de-Villegas,Galvez
, p. 261 - 268 (1994)
A strategy of highly selective alkylation of chiral 2-cyanoesters followed by the corresponding degradation process allows a divergent asymmetric synthesis of (R) and (S)-α-methylphenylalanine.
Asymmetric Synthesis of β-Lactams. Highly Diastereoselective Alkylation of Chiral 2-Cyano Esters
Cativiela, Carlos,Diaz-de-Villegas, Maria D.,Galvez, Jose A.
, p. 2497 - 2505 (2007/10/02)
Enolates derived from 10-(dicyclohexylsulfamoyl)isobornyl 2-substituted-2-cyanoacetates were alkylated with very good yield and high diastereoselectivity.The reduction of the resulting reaction products and subsequent cyclization of the β-amino acids led
Synthesis of (R)- and (S)-3-benzyl-3-methyl-2-azetidinone in enantiomerically pure form
Cativiela,Diaz-de-Villegas,Galvez
, p. 1141 - 1144 (2007/10/02)
The diastereoselective methylation of the enolate of 10-dicyclohexylsulfamoylisobornyl-3-phenyl-2-cyanopropanoate is reported. This methylation was carried out under a variety of conditions to achieve a good yield and selectivity and the reaction product
Chiral 2-Cyanocinnamates in Conjugate Addition Asymmetric Enolate Trapping Reactions
Cativiela, Carlos,Diaz-de-Villegas, Maria Dolores,Galvez, Jose Antonio
, p. 1657 - 1661 (2007/10/02)
Chiral 2-cyannocinnamates react with L-selectride to give an intermediate enolate which can be stereoselectively trapped with different halides to afford α-substituted phenylalanine precursors with excellent chemical yields and good diastereomeric excess.
