143100-56-5

Upstream product

• 143100-55-4 (S)-2-(p-Anisyloxy)-4-phenylbutanoic acid 
• 77-78-1 dimethyl sulfate 
• 139040-36-1 4-phenyl-1,1,1-trichloro-2-butanone 
• 139040-41-8 (R)-4-phenyl-1,1,1-trichloro-2-butanol 
• 16503-46-1 2-bromo-4-phenyl butanoic acid 
• 67-56-1 methanol 
• 1122-95-8 sodium 4-methoxyphenolate 
• 479350-68-0 (S,S)-N-methylpseudoephedrine 2-bromo-4-phenylbutanoate 

Downstream Products

• 129990-77-8 (2S)-2-Hydroxy-4-phenylbutyric acid methyl ester 

Relevant academic research and scientific papers

Dynamic thermodynamic resolution of N-methylpseudoephedrine α-bromo esters for asymmetric syntheses of α-hydroxy carboxylic acid derivatives

An example of dynamic thermodynamic resolution in the nucleophilic substitution reactions of α-bromo esters with an oxygen nucleophile is described. Temperature controlled epimerization-substitution sequence provides a practical protocol for the preparation of highly enantioenriched α-hydroxy carboxylic acid derivatives up to 72% yield with 99:1 er.

A new process for the enantioselective synthesis of chiral α-aryloxy- and α-hydroxy acids

Chiral trichloromethyl carbinols 3, readily available by catalytic enantioselective reduction of trichloromethyl ketones, are converted with inversion of configuration into chiral α-aryloxy and α-hydroxy carboxylic acid derivatives.