139040-36-1

Upstream product

• 104-53-0 3-phenyl-propionaldehyde 
• 82772-38-1 α-(trichloromethyl)benzenepropanol 

Downstream Products

• 1104059-09-7 C₁₀H₈⁽²⁾HCl₃O 
• 139040-47-4 (S)-2-Azido-4-phenyl-butyric acid 
• 943-73-7 D-homophenylalanine 
• 143100-55-4 (S)-2-(p-Anisyloxy)-4-phenylbutanoic acid 
• 143100-56-5 methyl (S)-2-p-anisyloxy-4-phenylbutanoate 
• 129990-77-8 (2S)-2-Hydroxy-4-phenylbutyric acid methyl ester 
• 153475-15-1 (R)-1-chloro-4-phenylbutan-2-ol 
• 141036-66-0 (R)-(2-phenylethyl)oxirane 
• 139040-41-8 (R)-4-phenyl-1,1,1-trichloro-2-butanol 
• 780760-99-8 (S)-4-phenyl-1,1,1-trichloro-2-butanol 

Relevant academic research and scientific papers

Synthesis of Trihalomethyl Ketones from Trihalomethyl Carbinols (Hal = Cl, Br) Using 2-Iodoxybenzoic Acid

Abstract: An efficient method for the preparation of trihalomethyl (Cl, Br) ketones by the oxidation of trihalomethyl carbinols with 2-iodoxybenzoic acid in tert-butanol under heating has been developed. A series of trihalomethyl ketones have been synthesized through a simple, convenient, and environmentally friendly method with excellent yields.

Application of piperazine structure containing compound to preparation of LSD1 (Lysine Specific Demethylase 1) inhibitor

The invention discloses application of a piperazine structure containing compound to the preparation of a histone lysine specific demethylase (LSD1) inhibitor. The structural general formula of the compound is as shown in the following descriptions (wherein, A is hydrogen, carbonyl or thiocarbonyl) or a configurational isomer and a pharmaceutical salt thereof, or is as shown in the following descriptions or a pharmaceutical salt thereof. The compound has an obvious inhibition effect on the LSD1, can be prepared into the LSD1 inhibitor, and is used for preventing and treating a disease related to the activity of the histone LSD1.

Trichloromethyl ketones: Asymmetric transfer hydrogenation and subsequent Jocic-type reactions with amines

Amino-amides are important pharmaceutical building-blocks. The enantioselective reduction of trichloromethyl ketones using ruthenium transfer hydrogenation catalysts is reported. The products react in a range of Jocic-type reactions to give enantiomerically enriched amino-amides.

Trichloromethyl ketones as synthetically versatile donors: Application in direct catalytic mannich-type reactions and the stereoselective synthesis of azetidines

Chemical transformers! Catalytic nucleophilic activation of trichloromethyl ketones allows applications in intermolecular carbon-carbon bond-forming reactions. Mannich adducts such as azetidines can be obtained from the primary products in high yield and syn selectivity. PG = protecting group. (Chemical Equation Presented)

Two effective procedures for the synthesis of trichloromethyl ketones, useful precursors of chiral α-amino and α-hydroxy acids

Trichloroacetic acid can be converted to trichloromethyl ketones in good yield by two practical new procedures, one involving the catalyzed reaction of trichloroacetic acid with aldehydes at 23°C followed by oxidation and the other utilizing the coupling