143127-81-5Relevant articles and documents
The synthesis and properties of unsymmetrical porphyrazines annulated with a tetrathiafulvalene bearing two tetraethylene glycol units
Leng, Fengshou,Wang, Xuesong,Jin, Longyi,Yin, Bingzhu
, p. 89 - 94 (2010)
A dicyano-tetrathiafulvalene precursor was prepared by the cross-coupling reaction of 4,5-dicyano-1,3-dithiol-2-one with 4,5-bis(3,6,9,12-tetraoxatridecylthio)-1,3-dithiol-2-thione. A Mg(II) template cyclization of the precursor with excess 2,3-bis(methylthio)maleonitrile gave the unsymmetrical magnesium porphyrazine, which was easily converted to the metal-free derivative by treatment with acetic acid in the dark. The metal-free porphyrazine was converted to the corresponding zinc porphyrazine in 75% yield. The products were fully characterized using spectroscopic data and elemental analysis. They were soluble in common organic solvents; solution electrochemical, UV-Vis and ESR data revealed that all porphyrazines formed an electron transfer complex with 7,7,8,8-tetracyanoquinodimethan and 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane.
GLYCOSIDE COMPOUND AND PREPARATION METHOD THEREFOR, COMPOSITION, APPLICATION, AND INTERMEDIATE
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Paragraph 0402; 0405, (2021/04/23)
The present invention discloses a glycoside compound represented by Formula III, and a preparation method, a composition, use and an intermediate thereof. The glycoside compound provided in the present invention has simple preparation method, can significantly increase the expression of VEGF-A mRNA, and is effective in promoting the angiogenesis. This provides a reliable guarantee for the development of drugs with pro-angiogenic activity for treating cerebral infarction cerebral stroke, myocardial infarction, and ischemic microcirculatory disturbance of lower limbs.
DESFERRITHIOCIN POLYETHER ANALOGUES AND USES THEREOF
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Page/Page column 51, (2011/04/14)
Desferrithiocin analogues represented by the structural formulae described here, such as formula (I), are useful in treating conditions such as metal overload (e.g., iron overload from transfusion therapy), oxidative stress, and neoplastic and preneoplast
The impact of polyether chain length on the iron clearing efficiency and physiochemical properties of desferrithiocin analogues
Bergeron, Raymond J.,Bharti, Neelam,Wiegand, Jan,McManis, James S.,Singh, Shailendra,Abboud, Khalil A.
experimental part, p. 2843 - 2853 (2010/08/22)
(S)-2-(2,4-Dihydroxyphenyl)-4,5-dihydro-4-methyl-4-thiazolecarboxylic acid (2) was abandoned in clinical trials as an iron chelator for the treatment of iron overload disease because of its nephrotoxicity. However, subsequent investigations revealed that replacing the 4′-(HO) of 2 with a 3,6,9-trioxadecyloxy group, ligand 4, increased iron clearing efficiency (ICE) and ameliorated the renal toxicity of 2. This compelled a closer look at additional polyether analogues, the subject of this work. The 3,6,9,12-tetraoxatridecyloxy analogue of 4, chelator 5, an oil, had twice the ICE in rodents of 4, although its ICE in primates was reduced relative to 4. The corresponding 3,6-dioxaheptyloxy analogue of 2, 6 (a crystalline solid), had high ICEs in both the rodent and primate models. It significantly decorporated hepatic, renal, and cardiac iron, with no obvious histopathologies. These findings suggest that polyether chain length has a profound effect on ICE, tissue iron decorporation, and ligand physiochemical properties.
