62921-76-0Relevant articles and documents
A Modular Synthetic Route Involving N-Aryl-2-nitrosoaniline Intermediates Leads to a New Series of 3-Substituted Halogenated Phenazine Antibacterial Agents
Yang, Hongfen,Kundra, Shivani,Chojnacki, Michaelle,Liu, Ke,Fuse, Marisa A.,Abouelhassan, Yasmeen,Kallifidas, Dimitris,Zhang, Peilan,Huang, Guangtao,Jin, Shouguang,Ding, Yousong,Luesch, Hendrik,Rohde, Kyle H.,Dunman, Paul M.,Lemos, José A.,Huigens, Robert W.
supporting information, p. 7275 - 7295 (2021/05/29)
Pathogenic bacteria demonstrate incredible abilities to evade conventional antibiotics through the development of resistance and formation of dormant, surface-attached biofilms. Therefore, agents that target and eradicate planktonic and biofilm bacteria are of significant interest. We explored a new series of halogenated phenazines (HP) through the use of N-aryl-2-nitrosoaniline synthetic intermediates that enabled functionalization of the 3-position of this scaffold. Several HPs demonstrated potent antibacterial and biofilm-killing activities (e.g., HP 29, against methicillin-resistant Staphylococcus aureus: MIC = 0.075 μM; MBEC = 2.35 μM), and transcriptional analysis revealed that HPs 3, 28, and 29 induce rapid iron starvation in MRSA biofilms. Several HPs demonstrated excellent activities against Mycobacterium tuberculosis (HP 34, MIC = 0.80 μM against CDC1551). This work established new SAR insights, and HP 29 demonstrated efficacy in dorsal wound infection models in mice. Encouraged by these findings, we believe that HPs could lead to significant advances in the treatment of challenging infections.
Self-assembly of Amphiphilic Porphyrins To Construct Nanoparticles for Highly Efficient Photodynamic Therapy
Jiang, Meiyu,Wu, Jiasheng,Liu, Weimin,Ren, Haohui,Zhang, Wenjun,Lee, Chun-Sing,Wang, Pengfei
, p. 11195 - 11204 (2021/06/01)
Hydrophobic photosensitizers greatly affect cell permeability and enrichment in tumors, but they cannot be used directly for clinical applications because they always aggregate in water, preventing their circulation in the blood and accumulation in tumor
The effect of the donor moiety of DPP based polymers on the performance of organic electrochemical transistors
Chen, Junxin,Hamidi-Sakr, Amer,Inal, Sahika,Li, Zhengke,Liao, Hailiang,Surgailis, Jokubas,Wang, Yazhou,Yue, Wan,Zhou, Yecheng,Zhu, Genming
supporting information, p. 13338 - 13346 (2021/10/14)
Organic mixed (ionic and electronic) charge conductors are the building blocks of state-of-the-art bioelectronic devices, including the organic electrochemical transistors (OECTs). Despite the interest in OECTs, the library of polymers that show efficient
