1431462-04-2Relevant articles and documents
Oligonucleotide functionalization by a novel alkyne-modified nonnucleosidic reagent obtained by versatile building block chemistry
Kupryushkin, Maxim S.,Konevetz, Dmitrii A.,Vasilyeva, Svetlana V.,Kuznetsova, Anastasia S.,Stetsenko, Dmitry A.,Pyshnyi, Dmitrii V.
, p. 306 - 319 (2013)
A convenient synthetic strategy has been designed to prepare an alkyne-modified synthon for automated DNA synthesis. It is based on the key O-DMTr-protected 4-(2-hydroxyethyl)morpholin-2,3-dione and building blocks obtained by its functionalization by var
Efficient functionalization of oligonucleotides by new achiral nonnucleosidic monomers
Kupryushkin, Maxim S.,Nekrasov, Mikhail D.,Stetsenko, Dmitry A.,Pyshnyi, Dmitrii V.
, p. 2842 - 2845 (2014/06/23)
A novel synthetic strategy has been designed for preparation of achiral nonnucleosidic phosphoramidite monomers for automated solid-phase oligonucleotide synthesis. It is based on O-DMTr-protected 4-(2-hydroxyethyl)- morpholine-2,3-dione as the key compound and a family of building blocks obtained by its ring-opening by primary aliphatic amines. A series of nonnucleosidic phosphoramidites containing various side-chain functionalities was synthesized, and corresponding oligodeoxyribonucleotides incorporating modified units in single or multiple positions along the chain were prepared.
