143206-01-3

Basic information

• Product Name: Benzenesulfonamide, N-[(4-cyanophenyl)methylene]-4-methyl-
• CAS NO: 143206-01-3
• Molecular Formula: C15H12N2O2S
• Molecular Weight: 284.338
• Mol File: 143206-01-3.mol
• Article Data: 31

Chemical Properties

• CAS DataBase Reference: Benzenesulfonamide, N-[(4-cyanophenyl)methylene]-4-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenesulfonamide, N-[(4-cyanophenyl)methylene]-4-methyl-(143206-01-3)
• EPA Substance Registry System: Benzenesulfonamide, N-[(4-cyanophenyl)methylene]-4-methyl-(143206-01-3)

Safety Data

• Hazardous Substances Data: 143206-01-3(Hazardous Substances Data)

Upstream product

• 70-55-3 toluene-4-sulfonamide 
• 105-07-7 4-cyanobenzaldehyde 
• 6873-55-8 p-tolylsulfinyl amide 
• 55962-05-5 [N-(p-tolylsulfonyl)imino]phenyliodinane 
• 4083-64-1 Tosyl isocyanate 
• 127-65-1 chloroamine-T 
• 4104-47-6 N-sulfinyl-p-toluenesulfonamide 

Downstream Products

• 1132667-73-2 diethyl 3-(4-cyanophenyl)-1-tosylaziridine-2,2-dicarboxylate 
• 1278585-52-6 C₂₅H₂₀N₂O₃S 
• 1357911-66-0 2-nitro-1-p-cyanophenyl-N-tosylethanamine 

Relevant articles and documents

Accelerated Reactivity Mechanism and Interpretable Machine Learning Model of N-Sulfonylimines toward Fast Multicomponent Reactions

We introduce chemical reactivity flowcharts to help chemists interpret reaction outcomes using statistically robust machine learning models trained on a small number of reactions. We developed fast N-sulfonylimine multicomponent reactions for understanding reactivity and to generate training data. Accelerated reactivity mechanisms were investigated using density functional theory. Intuitive chemical features learned by the model accurately predicted heterogeneous reactivity of N-sulfonylimine with different carboxylic acids. Validation of the predictions shows that reaction outcome interpretation is useful for human chemists.

Mild Darzens Annulations for the Assembly of Trifluoromethylthiolated (SCF3) Aziridine and Cyclopropane Structures

We report mild new annulation approaches to trisubstituted trifluoromethylthiolated (SCF3) aziridines and cyclopropanes via Darzens inspired protocols. The products of these anionic annulations, rarely studied previously, possess attractive features rendering them valuable building blocks for synthesis platforms. In this study, trisubstituted acetophenone nucleophiles bearing SCF3 and bromine substituents in their α position were shown to undergo [2 + 1] annulations with vinyl ketones and tosyl-protected imines under mild reaction conditions.

Ruthenium-Catalyzed Synthesis of Isoindolinones via Amide-Directed Addition of Aromatic C-H Bonds to Aldimines

Ruthenium-catalyzed addition of aromatic C-H bonds to aldimines is described. [RuCl2(p-cymene)]2 functions as an efficient catalyst to promote the coupling of aryl amides with aldimines in the presence of a catalytic amount of base to give the corresponding isoindolinone derivatives. The nature of the substituent at the N-atom of the amides is crucial for the efficient conversion of the substrates, and a p-toluenesulfonyl group is the functionality of choice. A variety of amides and aldimines participated in the present Ru-catalyzed reaction to furnish the corresponding isoindolinones in moderate to high yield.