143207-82-3

Upstream product

• 20878-92-6 (E)-2,4-dimethoxy-α-phenylcinnamic acid 
• 613-45-6 2,4-Dimethoxybenzaldehyde 
• 1449-46-3 benzyltriphenylphosphonium bromide 
• 100-39-0 benzyl bromide 
• 103-82-2 phenylacetic acid 
• 1100-88-5 benzyltriphenylphosphonium chloride 

Downstream Products

• 5814-81-3 trans-(2R,3R)-2-phenyl-3-(4-(trifluoromethoxy)phenyl)oxirane 
• 5814-81-3 cis-2-(4-methoxybenzenyl)-3-phenyl-oxirane 
• 68775-99-5 (E)-2,4-dimethoxystilbene 

Relevant academic research and scientific papers

THERAPEUTIC AGENTS FOR SKIN DISEASES AND CONDITIONS

The present invention relates to method(s) of treating a subject afflicted with a skin disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans- stilbene or a stilbene hybrid. A method of treating or reducing the likelihood of a skin disease or condition in a patient is an additional embodiment of the present invention. Preferred pharmaceutical compositions of the invention include nanoemulsions comprising a therapeutically effective amount of a substituted cis or trans-stilbene or stilbene hybrid and at least one antibiotic.

Synthesis of 2-phenylnaphthalenes from styryl-2-methoxybenzenes

A new simple and efficient method for the synthesis of 2-phenylnaphthalenes from electron-rich 1-styryl-2-methoxybenzenes has been described. The reaction proceeds via TFA catalyzed C-C bond cleavage followed by intermolecular [4+2]-Diels-Alder cycloaddition of an in situ formed styrenyl trifluoroacetate intermediate. The quantum chemical calculations identified the transition state for the cycloaddition reaction and helped in tracing the reaction mechanism. The method has been efficiently utilized for synthesis of the phenanthrene skeleton and a naphthalene-based potent and selective ER-β agonist. This journal is

Substituted CIS- and trans-stilbenes as therapeutic agents

The present invention relates to method(s) of treating a subject afflicted with cancer or a precancerous condition, an inflammatory disease or condition, and/or stroke or other ischemic disease or condition, the method comprising administering to the subject or patient in need a composition comprising a therapeutically effective amount of a substituted cis or trans-stilbene.

Synthesis and biological evaluation of 1,1-dichloro-2,3-diarylcyclopropanes as antitubulin and anti-breast cancer agents

Z-1,1-Dichloro-2,3-diphenylcyclopropane (1) is an effective anti-breast cancer agent in rodents and in cell culture. We recently determined that 1 inhibits tubulin assembly in vitro, and causes microtubule loss in breast cancer cells, leading to accumulat

Cis-trans isomerization and oxidation of radical cations of stilbene derivatives

Isomerization from cis stilbene derivatives (c-S (S = RCH=CHC6H5: 1, R = C6H5; 2, R = 4-CH3C6H4; 3, R = 4-CH3OC6H4 (= An); 4, R = 2,4-(CH3O)2C6H3; 5, R = 3,4-(CH3O)2C6H3; 6, R = 3,5-(CH3O)2C6H3; 7, AnCH=C(CH3)C6H5; 8, AnCH=CHAn)) to trans isomers (t-S) and oxidation of S with O2 were studied in γ-ray radiolyses of c-S in Ar-saturated 1,2-dichloroethane (DCE) and of S in O2-saturated DCE, respectively. On the basis of product analyses, it is suggested that a smaller barrier to c-t unimolecular isomerization for c-3.+-5.+ and 8.+ than for c-1.+, 2.+, and 6.+ due to the single bond character of the central C=C double bond for c-3.+-5.+ and 8.+ with a p-methoxyl group but not for c-l.+, 2.+, and 6.+ without a p-methoxyl group because of the contribution of a quinoid-type structure induced by charge-spin separation. The isomerization proceeds via chain reaction mechanisms involving c-t unimolecular isomerization and endergonic hole transfer or dimerization and decomposition. The isomerization of c-3.+ to t-3.+ is catalyzed by addition of 1,4-dimethoxybenzene but terminated by triethylamine. The regioselective formation of 3d in oxidation of 3.+ with O2 is explained by spin localization on the β-olefinic carbon in 3.+. The results of product analyses are compared with the rate constants of the unimolecular isomerization and the oxidation for S.+ measured with pulse radiolyses.