143212-74-2

Basic information

• Product Name: 2-[2-(3-Methoxyphenyl)ethenyl]phenol
• Synonyms: 2-[2-(3-Methoxyphenyl)ethenyl]phenol;2-Hydroxy-3'-methoxystilbene;2-(3-methoxystyryl)phenol
• CAS NO: 143212-74-2
• Molecular Formula: C₁₅H₁₄O₂
• Molecular Weight: 226.27
• EINECS: 1312995-182-4
• Mol File: 143212-74-2.mol

Chemical Properties

• Boiling Point: 379.1 °C at 760 mmHg
• Flash Point: 212.1 °C
• Appearance: white like or light brown crystalline powder
• Density: 1.159
• CAS DataBase Reference: 2-[2-(3-Methoxyphenyl)ethenyl]phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-(3-Methoxyphenyl)ethenyl]phenol(143212-74-2)
• EPA Substance Registry System: 2-[2-(3-Methoxyphenyl)ethenyl]phenol(143212-74-2)

Safety Data

• Hazardous Substances Data: 143212-74-2(Hazardous Substances Data)

Usage

Uses

Used in Chemical Synthesis:
2-[2-(3-Methoxyphenyl)ethenyl]phenol is used as a chemical intermediate for the synthesis of various organic compounds, taking advantage of its unique structure and reactivity.
Used in Pharmaceutical Industry:
2-[2-(3-Methoxyphenyl)ethenyl]phenol is used as a potential pharmaceutical candidate due to its specific chemical properties, which may offer new avenues for drug development and therapeutic applications.
Used in Material Science:
2-[2-(3-Methoxyphenyl)ethenyl]phenol is used as a component in the development of new materials, such as polymers or coatings, where its hydrophobic characteristics and reactivity could be beneficial.
Used in Research and Development:
2-[2-(3-Methoxyphenyl)ethenyl]phenol is used as a subject of study in scientific research to explore its potential applications, properties, and interactions with other compounds, furthering our understanding of its capabilities and limitations.

Upstream product

• 33223-21-1 C₂₆H₂₄ClOP 
• 90-02-8 salicylaldehyde 
• 60815-18-1 diethyl [(3-methoxyphenyl)methyl]phosphonate 
• 874-98-6 1-bromomethyl-3-methoxybenzene 
• 5533-04-0 2-(methoxymethoxy)benzaldehyde 
• 18880-05-2 3-methoxybenzyl-triphenylphosphonium chloride 
• 89-95-2 2-methyl-benzyl alcohol 

Downstream Products

• 1585206-18-3 1-[(3,4,5-trimethoxybenzyl)oxy]-2-[2-(3-methoxyphenyl)ethyl]benzene 
• 1585206-28-5 2-({2-[2-(3-methoxyphenyl)ethyl]phenoxy}methyl)thiophene 
• 1585206-27-4 5-({2-[2-(3-methoxyphenyl)ethyl]phenoxy}methyl)1,3-benzodioxole 
• 1585206-25-2 2-({2-[2-(3-methoxyphenyl)ethyl]phenoxy}methyl)pyrimidine 
• 135963-42-7 (R,S)-1-<2-<2-(3-methoxyphenyl)ethyl>phenoxy>-3-(dimethylamino)-2-propanol 
• 72279-22-2 2-(4-dimethylaminobutoxy)-3'-methoxybibenzyl 

Relevant articles and documents

A 2 - [2 - (3-methoxy-phenyl)-ethyl]-phenol synthesis method

The invention discloses a synthetic method for 2-[2-(3-methoxyphenyl)ethyl]phenol. The method comprises: firstly synthesizing diethyl 3-methoxybenzylphosphonate and 2,2-dimethoxybenzaldehyde, then successively synthesizing 1-(2,2-dimethoxyphenyl)-2-(3-methoxyphenyl)ethylene, 1-(2-phenoxy)-2-(3-methoxyphenyl)ethylene, 1-(2-acetoxphenyl)-2-(3-methoxyphenyl)ethylene and 1-(2-acetoxphenyl)-2-(3-methoxyphenyl)ethane, and finally synthesizing the product 2-[2-(3-methoxyphenyl)ethyl]phenol. The prepared 2-[2-(3-methoxyphenyl)ethyl]phenol product is good in quality and high in yield.

SAR study on arylmethyloxyphenyl scaffold: Looking for a P-gp nanomolar affinity

Starting from the previously developed P-gp ligands 1a and 1b (EC 50 = 0.25 μM and 0.65 μM, respectively), new arylmethyloxyphenyl derivatives have been synthesized as P-gp modulators in order to investigate: (i) the effect of small electron-do

1-PHENYLALCOXY-2-BETA-PHENYLETHYL DERIVATIVES AS P-GLYCOPROTEIN (P-GP) INHIBITORS USEFUL IN DRUG RESISTANCE EVENTS

The invention relates to a new class of compounds, which are 1-phenylalcoxy-2-β-phenylethyl derivatives, as P-glycoprotein (P-GP) inhibitors. These compounds are useful in drug resistance events. They have been shown able to inhibit in a dose-dependent ma

Arylmethyloxyphenyl derivatives: Small molecules displaying P-glycoprotein inhibition

Some arylmethyloxyphenyl derivatives were prepared as simplified structures of analogous arylpiperazines with high affinity toward dopaminergic D 2 and serotonergic 5-HT1A receptors and inhibiting P-glycoprotein (P-gp). The compounds 5b and 8b displayed good P-gp inhibition activity measured as [3H]vinblastine transport inhibition in the Caco-2 cell monolayer and intracellular doxorubicin accumulation in MCF7/Adr cells by flow cytometry. Compounds 5b and 8b also inhibited, dose-dependently, ATP-ase activation induced by P-gp substrate vinblastine.

Syntheses and Platelet Aggregation Inhibitory and Antithrombotic Properties of ethyl>benzenes

A series of ethyl>benzene derivatives were synthesized and evaluated for their ability to inhibit collagen-induced platelet aggregation in vitro and to protect experimantal thrombosis in mice.The results showed that the compounds were in vitro inhibitors of collagen-induced platelet aggregation.Most of them were also effective in the mouse antithrombotic assay.The compounds were found to be potent antagonists to S2 serotonergic receptor, and good correlation (r = 0.85) between their S2 serotonergic receptor antagonism and their potency as platelet antiaggregatory drugs was observed.Among the compounds studied, monophenoxy>methyl>ethyl>succinate hydrochloride (12b, MCI-9042) was selected for further pharmacological and toxicological evaluation.