143232-64-8

Upstream product

• 15450-69-8 5,6,7,8-tetrahydro-5-oxo-2(1H)-quinolinone 
• 100-39-0 benzyl bromide 
• 5220-49-5 3-amino-cyclohex-2-enone 

Downstream Products

• 143232-76-2 O-benzyl-N-(2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-hydroxylamine 
• 143246-85-9 5,6,7,8-tetrahydro-2-(phenylmethoxy)-5-(phenylmethyl)-5-quinolinamine 
• 143246-86-0 5,6,7,8-tetrahydro-N,2-bis(phenylmethoxy)-5-(phenylmethyl)-5-quinolinamine 
• 143246-81-5 2-Benzyloxy-5-benzyloxyamino-5,6,7,8-tetrahydro-5-methyl-quinoline 
• 286381-98-4 Tetradecanedioic acid bis-[((S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-amide] 
• 286381-97-3 Tridecanedioic acid bis-[((S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-amide] 
• 286382-04-5 N,N'-bis-(2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-tetradecane-1,14-diamine 
• 286381-96-2 Dodecanedioic acid bis-[((S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-amide] 
• 286382-03-4 N,N'-bis-(2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-tridecane-1,13-diamine 
• 286382-01-2 N,N'-bis-(2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-dodecane-1,12-diamine 
• 286381-95-1 Undecanedioic acid bis-[((S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-amide] 
• 286381-94-0 Decanedioic acid bis-[((S)-2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-amide] 
• 286382-00-1 N,N'-bis-(2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-undecane-1,11-diamine 
• 286381-99-5 N,N'-bis-(2-benzyloxy-5,6,7,8-tetrahydro-quinolin-5-yl)-decane-1,10-diamine 

Relevant academic research and scientific papers

Heterodimers and Methods of Using Them

Novel heterodimers of tetrahydroacridines and tetrahydroquinolinones are disclosed. The heterodimers are capable of acting as both acetylcholinesterase inhibitors and N-methyl-D-aspartate (NMDA) receptor antagonists. The heterodimers may be used to improve cognitive defects via treatment or prevention in both humans and non-humans.

NOVEL NUCLEAR HORMONE RECEPTOR LIGANDS AND METHODS

The present invention relates to compounds and derivatives thereof, their synthesis, and their use as nuclear hormone receptor modulators. The compounds of the instant invention are ligands for nuclear hormone receptors and as such may be useful for treat

A solution-phase procedure for the preparation of 4-azasteroid mimetics

A Diels-Alder approach has been employed to make 3-oxo-octahydro-benzo[f] quinoline derivatives as ligands for nuclear hormone receptors and steroid biosynthetic enzymes. The five-step synthesis is a model for the synthesis of libraries on solid-phase.

Dimeric compounds

The invention relates to dimeric compounds comprising two 5-amino-5,6,7,8-tetrahydroquinoline fragments joined together by a divalent linking group, processes for their preparation, intermediates for their preparation, pharmaceutical compositions containing such dimeric compounds and the use of such compounds as cholinesterase inhibitors and in the treatment of neurodegenerative diseases, such as Alzheimer's Disease and myasthenia gravis.

Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer's Disease

A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors.The compounds are related to hyperzine A, a naturally occurring cholinesterase inhibitor.They inhibit acetylcholinesterase in vitro, and man

5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use

Novel 5-amino-5,6,7,8-tetrahydroquinolines and related compounds, intermediates and processes for the preparation thereof, and methods for relieving memory dysfunction utilizing compounds or compositions thereof are disclosed.