143232-65-9Relevant academic research and scientific papers
Dimeric compounds
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, (2008/06/13)
The invention relates to dimeric compounds comprising two 5-amino-5,6,7,8-tetrahydroquinoline fragments joined together by a divalent linking group, processes for their preparation, intermediates for their preparation, pharmaceutical compositions containing such dimeric compounds and the use of such compounds as cholinesterase inhibitors and in the treatment of neurodegenerative diseases, such as Alzheimer's Disease and myasthenia gravis.
Synthesis and Evaluation of 5-Amino-5,6,7,8-tetrahydroquinolinones as Potential Agents for the Treatment of Alzheimer's Disease
Fink, David M.,Bores, Gina M.,Effland, Richard C.,Huger, Francis P.,Kurys, Barbara E.,et al.
, p. 3645 - 3651 (2007/10/03)
A series of 5-amino-5,6,7,8-tetrahydroquinolinones was designed and synthesized as acetylcholinesterase inhibitors.The compounds are related to hyperzine A, a naturally occurring cholinesterase inhibitor.They inhibit acetylcholinesterase in vitro, and man
5-amino-5,6,7,8-tetrahydroquinolines and related compounds and pharmaceutical use
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, (2008/06/13)
Novel 5-amino-5,6,7,8-tetrahydroquinolines and related compounds, intermediates and processes for the preparation thereof, and methods for relieving memory dysfunction utilizing compounds or compositions thereof are disclosed.
