1432447-63-6Relevant articles and documents
Gold(I)-catalyzed formation of bicyclo[4.2.0]oct-1-enes
Felix, Ryan J.,Gutierrez, Osvaldo,Tantillo, Dean J.,Gagné, Michel R.
, p. 5685 - 5690 (2013)
Gold(I) catalysts effectively promote the Cope rearrangement of acyclic 1,5-dienes bearing a terminal cyclopropylidene. When this methodology is applied to cyclic substrates an unexpected transformation occurs, resulting in the formation of a tricyclic compound incorporating a bicyclo[4.2.0]oct-1-ene core, a portion of which is found in a number of natural products. Density functional theory calculations (M06 and M06-2X) reveal insight into the mechanism and thermodynamics of this unique transformation.