143264-63-5Relevant academic research and scientific papers
The coupling of alkylboronic acids with α-(trifluoromethyl)styrenes by Lewis base/photoredox dual catalysis
Chen, Yuefeng,Ni, Niannian,Cheng, Dongping,Xu, Xiaoliang
, (2020/09/21)
Under Lewis base/photoredox dual catalysis, the defluorinative alkylation of alkylboronic acids with α-(trifluoromethyl)styrenes has been reported. In this system, both primary and secondary alkyl radicals produced by alkylboronic acids can react with α-(trifluoromethyl)styrenes to generate alkylated gem-difluoroalkenes. In general, the method has mild conditions, a wide substrate scope, and good functional group tolerance, which provides a new route for the synthesis of gem-difluoroalkenes.
