17745-45-8 Usage
Uses
Used in Pharmaceutical Industry:
Propylboronic acid is used as a chemical reagent for the synthesis of pharmaceutical agents, specifically for the production of inhibitors of mTOR, which are used in anti-tumor treatments. It plays a crucial role in the development of drugs that target the mTOR pathway, a key regulator of cell growth and proliferation, and is often dysregulated in various types of cancer.
Used in Organic Synthesis:
Propylboronic acid is also used as a reagent in the synthesis of endothelial lipase inhibitors. These inhibitors are important for the development of treatments targeting cardiovascular diseases, as they can help regulate lipid metabolism and prevent the formation of atherosclerotic plaques.
Used in Suzuki Reaction:
In addition to its applications in the pharmaceutical industry, propylboronic acid is also used in the Suzuki reaction, a widely employed cross-coupling reaction in organic chemistry. This reaction allows for the formation of carbon-carbon bonds between an organoboronic acid and an organic halide or triflate, enabling the synthesis of various organic compounds, including complex molecules and pharmaceutical agents.
Check Digit Verification of cas no
The CAS Registry Mumber 17745-45-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,7,7,4 and 5 respectively; the second part has 2 digits, 4 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 17745-45:
(7*1)+(6*7)+(5*7)+(4*4)+(3*5)+(2*4)+(1*5)=128
128 % 10 = 8
So 17745-45-8 is a valid CAS Registry Number.
InChI:InChI=1/C3H9BO2/c1-2-3-4(5)6/h5-6H,2-3H2,1H3
17745-45-8Relevant academic research and scientific papers
A Revised Modular Approach to (–)-trans-Δ8-THC and Derivatives Through Late-Stage Suzuki–Miyaura Cross-Coupling Reactions
Bloemendal, Victor R. L. J.,Sondag, Daan,Elferink, Hidde,Boltje, Thomas J.,van Hest, Jan. C. M.,Rutjes, Floris P. J. T.
, p. 2289 - 2296 (2019/04/03)
A revised modular approach to various synthetic (–)-trans-Δ8-THC derivatives through late-stage Suzuki–Miyaura cross-coupling reactions is disclosed. Ten derivatives were synthesized allowing both sp2- and sp3-hybridized cross-coupling partners with minimal β-hydride elimination. Importantly, we demonstrate that a para-bromo-substituted THC scaffold for Suzuki–Miyaura cross-coupling reactions has been initially reported incorrectly in recent literature.
