143317-74-2 Usage
General Description
Erucylphosphocholine, also known as ErPC or erufosine, is a synthetic lipid compound with potential anticancer and anti-inflammatory properties. It has been studied for its ability to induce apoptosis (cell death) in cancer cells and has shown some promise in early clinical trials for the treatment of various cancers, including pancreatic and colorectal cancer. Erucylphosphocholine is thought to act by disrupting the cell membrane and altering lipid metabolism, which ultimately leads to cancer cell death. In addition to its potential as an anticancer agent, erucylphosphocholine has also been investigated for its anti-inflammatory effects, with some evidence suggesting it may have a role in reducing inflammation in conditions such as arthritis. Further research is needed to fully understand the potential therapeutic uses of erucylphosphocholine and its mechanisms of action.
Check Digit Verification of cas no
The CAS Registry Mumber 143317-74-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,4,3,3,1 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 143317-74:
(8*1)+(7*4)+(6*3)+(5*3)+(4*1)+(3*7)+(2*7)+(1*4)=112
112 % 10 = 2
So 143317-74-2 is a valid CAS Registry Number.
InChI:InChI=1/C27H56NO4P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20-21-22-23-24-26-31-33(29,30)32-27-25-28(2,3)4/h12-13H,5-11,14-27H2,1-4H3/b13-12-
143317-74-2Relevant articles and documents
Antitumor phospholipids: A one-pot introduction of a phosphocholine moiety into lipid hydroxy acceptors
Erukulla, Ravi Kumar,Byun, Hoe-Sup,Bittman, Robert
, p. 5783 - 5784 (1994)
A high-yielding, 3-step, one-pot conversion of lipid hydroxy acceptors 2 into clinically useful alkylphosphocholines 1 is reported. Reaction of 2 with ethylene chlorophosphite gave phosphite 3, which underwent oxidation and ring opening with bromine in CH2Cl2 to give (2-bromoethyl)phosphate ester 4; hydrolysis of the P-Br bond and quaternization of 4 with aqueous trimethylamine generated 1.
