14333-95-0

Upstream product

• 37593-02-5 4-n-pentylacetophenone 
• 49763-65-7 4-pentylbenzoyl chloride 
• 538-68-1 pentylbenzene 
• 64328-68-3 2-bromo-1-(4-pentylphenyl)ethan-1-one 
• 138913-07-2 4-n-pentylbenzamide 
• 10270-29-8 p-n-pentylbenzonitrile 
• 26311-45-5 4-pentylbenzoic acid 

Downstream Products

• 94775-61-8 Potassium; 2-[1-hydroxy-2-oxo-2-(4-pentyl-phenyl)-ethyl]-3-oxo-hexanoate 
• 1092390-04-9 4-(4-pentylphenyl)-1,3-dihydroimidazole-2-thione 
• 1092390-05-0 1-hydroxy-4-(4-pentylphenyl)-1,3-dihydroimidazole-2-thione 
• 1092390-06-1 1-hydroxy-5-(4-pentylphenyl)-1,3-dihydroimidazole-2-thione 
• 94775-70-9 2-Hydroxy-1-(4-pentyl-phenyl)-heptane-1,4-dione 
• 94775-80-1 3-(4-Pentyl-phenyl)-6-propyl-pyridazine 

Relevant academic research and scientific papers

One-pot three-component reactions of methyl ketones, phenols and a nucleophile: An expedient way to synthesize densely substituted benzofurans

Three-component reactions of phenylglyoxal monohydrate, phenols, and indoles were developed with the aid of acid-catalyst, which produced various densely substituted benzofurans with good to excellent yields. On the basis of this observation, a one-pot, step-wise reaction was developed by using methyl ketones instead of using phenylglyoxal component in I2/DMSO system. At last, three-component reaction offered a useful way to synthesize densely substituted benzofurans starting from simple and easily available substrates. The indole component can be replaced by some other nucleophiles, such as 1,2,4-trimethoxybenzene and thiophenol.

NOVEL 4-PHENYLIMIDAZOLE-2-THIONE TYROSINASE INHIBITORS AND PHARMACEUTICAL/COSMETIC APPLICATIONS THEREOF

Novel 4-phenylimidazole-2-thione tyrosinase inhibiting compounds corresponding to the following general formula (I): formulated into pharmaceutical or cosmetic compositions are useful for the treatment or prevention of pigmentary disorders, or for preventing and/or treating signs of skin aging, and/or for body or hair hygiene.

3-ALKYLIDENEHYDRAZINO SUBSTITUTED HETEROARYL COMPOUNDS AS THROMBOPOIETIN RECEPTOR ACTIVATORS

A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14; aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13, SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10; alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14; aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.

Inhibitors of anthrax lethal factor activity

Methods and compositions that act as specific inhibitors of ALF activity for the prophylaxis and treatment of anthrax infections.

Synthesis and Liquid Crystalline Phases of Pyridazine Derivatives II

Four more pyridazine compounds were synthesized.The compounds have a general structure R-X-Y-Z-R'; where Y is 3,6 disubstituted pyridazine ring, X and Z are either trans cyclohexyl or phenyl rings, R and R' are n-alkyl groups.The structure assignments were confirmed by carbon 13 NMR.Their liquid crystalline properties were evaluated.When both X and Z are cyclohexyl rings, the compounds have a single smectic b phase.However, if a phenyl ring is introduced into the system, the morphology becomes complicated.Keywords: synthesis, pyridazine, smectic, classification

The Synthesis of 3-Aryl-6-alkylpyridazines

Nine compounds of general structure R-X-Y-R' where X is a para-disubstituted phenyl ring and Y is a 3,6-disubstituted-pyridazine ring were synthesized.These can be used as liquid crystal dopents.A general procedure for their synthesis was developed.N-Alkyl benzene and ethyl butyrylacetate were used as starting materials.The purification of reaction intermediates was not necessary if preparative hplc was used to purify the final products.Very pure materials were obtained with good yield.Their structure was confirmed by carbon 13 nmr.