10270-29-8

Basic information

• Product Name: 4-PENTYLBENZONITRILE
• Synonyms: P-PENTYLBENZONITRILE;4-N-PENTYLBENZONITRILE;4-PENTYLBENZONITRILE;p-Cyanopentylbenzene.
• CAS NO: 10270-29-8
• Molecular Formula: C₁₂H₁₅N
• Molecular Weight: 173.25
• Product Categories: Aromatic Nitriles
• Mol File: 10270-29-8.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 278.9 °C at 760 mmHg
• Flash Point: 122.7 °C
• Appearance: /
• Density: 0.95g/cm³
• Vapor Pressure: 0.00414mmHg at 25°C
• Refractive Index: 1.51
• CAS DataBase Reference: 4-PENTYLBENZONITRILE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-PENTYLBENZONITRILE(10270-29-8)
• EPA Substance Registry System: 4-PENTYLBENZONITRILE(10270-29-8)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R20/21/22:Harmful by inhalation, in contact with skin and if swallowed.
• Safety Statements: S36/37:Wear suitable protective clothing and gloves.
• Hazardous Substances Data: 10270-29-8(Hazardous Substances Data)

Usage

General Description

4-Pentybenzonitrile, also known as Benzonitrile,4'-pentyl, is a chemical compound with the molecular formula C12H15N. It is commonly used as an intermediate in the production of other chemicals and pharmaceuticals. It is a clear, colorless fluid that has a pleasant, almond-like odor. It is soluble in most organic solvents and slightly soluble in water. It's boiling point is around 317.2±25.0°C while melting point is around -31.6±7.0 °C. Its chemical nature can cause irritation to the skin and eyes on direct contact. 4-Pentybenzonitrile is a hazardous substance that should be handled with proper safety measures.

InChI:InChI=1/C12H15N/c1-2-3-4-5-11-6-8-12(10-13)9-7-11/h6-9H,2-5H2,1H3

Upstream product

• 109-65-9 1-bromo-butane 
• 104-85-8 para-methylbenzonitrile 
• 100-46-9 benzylamine 
• 14906-59-3 4-cyanopyridine N-oxide 
• 85017-60-3 4-iodine-pentyl benzene 
• 623-26-7 terephthalonitrile 
• 10051-44-2 sodium caproate 
• 85-01-8 phenanthrene 
• 49763-65-7 4-pentylbenzoyl chloride 
• 26311-45-5 4-pentylbenzoic acid 
• 138913-07-2 4-n-pentylbenzamide 

Downstream Products

• 127464-91-9 1-(4-Pentyl-phenyl)-2-phenyl-ethanone 
• 14333-95-0 4-pentylbenzoylformaldehyde 
• 29147-99-7 p-n-pentylbenzamidinium chloride 
• 37593-02-5 4-n-pentylacetophenone 

Relevant articles and documents

Reductive activation of arenes: XVII. Effect of methyl substituent in anion-radicals of tolunitriles on the mechanism of their reaction with alkyl bromides in liquid ammonia

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Nickel-Catalyzed Cyanation of Aryl Halides and Hydrocyanation of Alkynes via C-CN Bond Cleavage and Cyano Transfer

We report nickel-catalyzed cyanation and hydrocyanation methods to prepare aryl nitriles and vinyl nitriles from aryl halides and alkynes, respectively. Using inexpensive and nontoxic 4-cyanopyridine N-oxide as the cyano shuttle, the methods provide an efficient approach to prepare aryl cyanides and vinyl nitriles under mild and operationally simple reaction conditions with a broad range of functional group tolerances. In hydrocyanation of alkynes, the method demonstrated good regioselectivity, producing predominantly E- or Z-alkenyl nitriles in a controlled manner and exclusively Markovnikov vinyl nitriles when internal diaryl alkynes and terminal alkynes were applied as the substrates, respectively. The preliminary mechanistic investigation indicated that the C-CN bond cleavage process is promoted by oxidative addition to the nickel(I) complex in the cyanation of aryl halides, and further studies via a series of deuterium exchange experiments indicated that water serves as the hydrogen source for the hydrocyanation of alkynes.

SUBSTITUTED AMINOALKYLAZOLES AS MALARIAL ASPARTIC PROTEASE INHIBITORS

The present invention relates to novel aminoalkylazoles acting as inhibitors of malarial protease plasmepsin II. These can be used as medicines or as constituent of medicines for the treatment of malaria infection.

Decarboxylative photosubstitution of dicyanobenzenes with aliphatic carboxylate ions

The photoreaction of dicyanobenzenes with aliphatic carboxylate ions afforded alkylcyanobenzenes and alkyldicyanobenzenes via decarboxylative substitution. The redox-photosensitized reaction system was effective in improving the product yield. The efficie