143435-52-3

Basic information

• Product Name: N N' N -TRIHYDROXYISOCYANURIC ACID
• Synonyms: 1,3,5-Triazine-2,4,6(1H,3H,5H)-trione,1,3,5-trihydroxy-;1,3,5-Trihydroxyhexahydro-1,3,5-triazine-2,4,6-trione;1,3,5-trihydroxy-1,3,5-Triazine-2,4,6(1H,3H,5H)-trione
• CAS NO: 143435-52-3
• Molecular Formula: C₃H₃N₃O₆
• Molecular Weight: 177.07242
• Mol File: 143435-52-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 240-244 °C (dec.)(lit.)
• Boiling Point: 466.4±28.0 °C(Predicted)
• Appearance: /
• Density: 2.946±0.06 g/cm3(Predicted)
• PKA: 8.29±0.20(Predicted)
• CAS DataBase Reference: N N' N -TRIHYDROXYISOCYANURIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: N N' N -TRIHYDROXYISOCYANURIC ACID(143435-52-3)
• EPA Substance Registry System: N N' N -TRIHYDROXYISOCYANURIC ACID(143435-52-3)

Safety Data

• Hazard Codes: T
• Statements: 61
• Safety Statements: 53-45
• WGK Germany: 1
• Hazardous Substances Data: 143435-52-3(Hazardous Substances Data)

Usage

General Description

N,N',N'-Trihydroxyisocyanuric Acid, often abbreviated as THICA, is a chemical compound with the molecular formula C3H5N3O6. This colorless, odorless substance is a chemical derivative of cyanuric acid, specifically its triol tautomer. It's known for its properties as an effective biocide, with a broad spectrum of activity against many different types of organisms, particularly bacteria and fungi. Used predominantly in both commercial and residential water treatment systems for its ability to balance pH levels and prevent the growth of harmful organisms, THICA is an essential component in maintaining the safety and cleanliness of water sources. However, like many chemical substances, it should be handled with care due to its potential hazards. It can potentially cause eye and skin irritation if exposed, and it's important to use it in well-ventilated areas and use protective gear as appropriate.

Upstream product

• 606-03-1 1,3,5-tribenzyl-[1,3,5]triazinane-2,4,6-trione 
• 95705-20-7 1,3,5-tribenzyloxy-1,3,5-triazine-2,4,6(1H,3H,5H)-trione 

Downstream Products

• 2345-34-8 4-acetyloxy-benzoic acid 
• 6304-89-8 3-acetoxybenzoic acid 
• 552-16-9 ortho-nitrobenzoic acid 
• 74-11-3 para-chlorobenzoic acid 

Relevant articles and documents

Aerobic oxidation of trimethylbenzenes catalyzed by N,N′,N″-trihydroxyisocyanuric acid (THICA) as a key catalyst

The oxidation of trimethylbenzenes was examined with air or O2 using N,N′,N″-trihydroxyisocyanuric acid (THICA) as a key catalyst. Thus, 1,2,3-, 1,2,4-, and 1,3,5-trimethylbenzenes under air (20 atm) in the presence of THICA (5 mol %), Co(OAc)2 (0.5 mol %), Mn(OAc)2, and ZrO(OAc)2 at 150 °C were oxidized to the corresponding benzenetricarboxylic acids in good yields (81-97%). In the aerobic oxidation of 1,2,4-trimethylbenzene by the THICA/Co(II)/Mn(II) system, remarkable acceleration was observed by adding a very small amount of ZrO(OAc)2 to the reaction system to form 1,2,4-benzenetricarboxylic acid in excellent yield (97%). In contrast, no considerable addition effect was observed in the oxidation of 1,3,5-trimethylbenzene. This aerobic oxidation by the present catalytic system provides an economical and environmentally benign direct method to benzenetricarboxylic acids, which are very important polymer materials.

Metal-Free: A novel and efficient aerobic oxidation of primary amines to oximes using N, N', N''-trihydroxyisocyanuric acid and acetaldoxime as catalysts in water

A general, efficient, and metal-free method for aerobic oxidation of aromatic primary amines to the corresponding oximes catalyzed by N,N',N''-trihydroxyisocyanuric acid and acetaldoxime with water as solvent is described. This practical method can use air as economic and green oxidant, water as green solvent, and tolerates a wide range of substrates, which can afford the target oximes in moderate to good yields. Georg Thieme Verlag Stuttgart. New York.

Development of an efficient method for preparation of 1,3,5- trihydroxyisocyanuric acid (THICA) and its use as aerobic oxidation catalyst

1,3,5-Trihydroxyisocyanuric acid (THICA), which serves as an efficient radical-producing catalyst from hydrocarbons, was successfully prepared by two methods. The reaction of O-benzylhydroxyamine with phenyl chloroformate gave formbenzyloxycarbamic acid phenyl ester of which subsequent treatment with dimethylaminopyridine (DMAP) produced 1,3,5-tribenzyloxyisocyanurate leading to THICA by hydrogenation with H2 on Pd/C. The other method involved the direct synthesis of 1,3,5-tribenzyloxyisocyanurate from O-benzylhydroxyamine and diphenyl carbonate. The aerobic oxidation of p-methylanisole catalyzed using THICA as a key catalyst afforded p-anisic acid in almost quantitative yield (>99%).