143468-08-0Relevant academic research and scientific papers
Preparation method of 6-cyano-7-azaindole and derivative thereof
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Paragraph 0030-0032, (2020/09/30)
The invention discloses a preparation method of 6-cyano-7-azaindole and a derivative thereof, which comprises the following steps: dissolving a compound represented by formula (1) in a solvent, and performing a reaction with an organic alkali and a cyaniding reagent under the action of a catalyst to obtain the final product represented by formula (2). According to the process disclosed by the invention, the safe and non-toxic potassium ferrocyanide is used as a cyano source, the reaction operation is simple and convenient, the yield is high, the influence on the environment is relatively small, and the process is suitable for preparing the 6-cyano-7-azaindole and the derivative 1-benzoyl-6-cyano-7-azaindole thereof on a large scale.
Regioselective functionalization of 1H-pyrrolo[2,3-b]pyridine via its N-oxide
Minakata,Komatsu,Ohshiro
, p. 661 - 663 (2007/10/02)
Selective functionalization of 1H-pyrrolo[2,3-b]pyridine (7-azaindole) at the 6-position was achieved by Reissert-Henze type reaction. Thus, halogeno (Cl, Br, I), cyano and thiocyanato groups were directly introduced to the pyridine ring of 7-azaindole.
