1435-01-4

Usage

Uses

Used in Pharmaceutical Industry:
Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)is used as a building block in organic synthesis for the development of new pharmaceutical compounds. Its unique structure allows for the creation of novel drug candidates with potential therapeutic applications.
Used in Agricultural Industry:
In the agricultural sector, Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)is utilized as a building block for the synthesis of agrochemicals, such as pesticides and fungicides. Its antifungal and antimicrobial properties make it a promising candidate for the development of effective crop protection agents.
Used in Research and Development:
Due to its unique structure and potential biological activities, Hydrazinecarbothioamide, N-phenyl-2-(2-thienylmethylene)is an interesting target for further research and development. Scientists are exploring its potential applications in medicine and agriculture, as well as its synthesis and modification for improved properties and efficacy.

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 5351-69-9 4-Phenyl-3-thiosemicarbazide 
• 26152-25-0 methyl 1-(thiophene-2-ylmethylene)-hydrazinecarbodithioate 
• 62-53-3 aniline 
• 103-72-0 phenyl isothiocyanate 

Downstream Products

• 1026792-44-8 N-phenyl-5-(thiophen-2-yl)-1,3,4-thiadiazole-2-amine 
• 1093399-56-4 4-amino-2,7-dinitro-4'-phenylspiro(fluoren-9,3'-[1,2,4]triazolidine)-5'-thione-1-(thiophen-2-carbonyl) 
• 84409-01-8 4-amino-2,7-dinitro-9-fluorenone 
• 1093399-50-8 [4-phenyl-1-(thiophen-2-carbonyl)-3-thioxo-1,2,4-triazaspiro[4.5]deca-6,9-dien-8-ylidene]malononitrile 
• 1093399-44-0 4a-hydroxy-3-(thiophene-2-yl)indeno[1,2-e][1,3,4]oxadiazine-9(4aH)-one 
• 1093399-45-1 3-cyano-4-oxo-N-phenylideno[1,2-c]pyrazole-1(4H)-carbothioamide 
• 1174624-61-3 methyl [3-(2-thienyl)-4-oxo-1-(phenylthiocarbamoyl)-4,5-dihydro-1H-pyrazol-5-ylidene]ethanoate 
• 1174624-73-7 ethyl 3-amino-6-(2-thienyl)-5-cyanopyridazine-4-carboxylate 
• 1174624-67-9 ethyl [3-(2-thienyl)-4-oxo-1-(phenylthiocarbamoyl)-4,5-dihydro-1H-pyrazol-5-ylidene]cyanoacetate 
• 110591-15-6 [Zn(Httsc-N-Ph)₂] 
• 1174196-53-2 Ni(C₄H₃S(CHNNC(S)NHC₆H₅))2 
• 110591-16-7 Cu(C₄H₃S(CHNNC(S)NHC₆H₅))2 
• 47107-74-4 tetrameric (triphenylphosphine)copper(I) iodide 

Relevant academic research and scientific papers

Inhibitory effect of synthetic aromatic heterocycle thiosemicarbazone derivatives on mushroom tyrosinase: Insights from fluorescence, 1H NMR titration and molecular docking studies

Three structurally similar aromatic heterocyclic compounds 2-thiophenecarboxaldehyde (a), 2-furaldehyde (b), 2-pyrrolecarboxaldehyde (c) were chosen and a series of their thiosemicarbazone derivatives(1a-3a, 1b-3b and 1c-3c) were synthesized to evaluate t

Fabrication of a Ho3+-PVC membrane sensor based on N-phenyl-2-(thiophen-2-ylmethylene)hydrazinecarbothioamide for determination of holmium ions

In this research, a new poly(vinyl chloride) (PVC) membrane sensor for Ho3+ ion based on N-phenyl-2-(thiophen-2-ylmethylene) hydrazinecarbothioamide (PHC) as an ionophore was prepared. This sensor demonstrated good selectivity and sensitivity t

Efficient synthesis of novel 2,3-dihydro-1,3,5,4-thiadiazaphosphole derivatives

ABSTRACT: The condensation of various thiosemicarbazones with methyl thiophene-2-carboximidate afforded the corresponding intermediates 2a–2h. Subsequent cyclization of the latter compounds with hexamethylphosphorous triamide constitutes a new route to the synthesis of novel highly functionalized thiadiazaphosphole derivatives 4a–4h. This method offers significant advantages such as efficiency, high yields and mild reaction conditions.

Copper compound taking 2-thiophenecarboxaldehyde thiosemicarbazone as ligand and synthesis method of copper compound

The invention discloses a copper compound taking 2-thiophenecarboxaldehyde thiosemicarbazone as a ligand and a synthesis method of the copper compound. The synthesis method comprises the following steps: adding thiosemicarbazone into absolute ethyl alcohol, performing stirring and dissolution, adding 2-thiophenecarboxaldehyde, performing uniform mixing, stirring the mixed solution at 70 DEG C in awater bath, performing volatilization at room temperature, separating a crystal so as to obtain a ligand; and adding the prepared ligand into absolute ethyl alcohol, performing stirring and dissolving, adding CuBr2.2H2O after dissolution, performing stirring at 70 DEG C in a water bath, performing volatilization at room temperature, and separating out a crystal, so as to obtain a Cu compound of the ligand. An in-vitro proliferation inhibition activity experiment is further carried out on the synthesized copper compound, results show that the synthesized series of copper compounds have generally good in-vitro activity, particularly have high specificity on human T24 and HeLa cells, show good inhibitory activity, have little toxic effect on human normal cells, and are suitable for preparingefficient and low-toxicity anti-tumor drugs.

Ion flotation and flame atomic absorption spectrophotometric determination of nickel and cobalt in environmental and pharmaceutical samples using a thiosemicarbazone derivative

THIOPHENE-2-Carboxaldhyde-4-Phenyl thiosemicarbazone (TAPT), a NS containing ligand, combines with Ni (II) and Co (II) each individually and in combination, to form complexes in aqueous solution. These complexes could be successfully separated by a surfac

For treating liver cancer of organic compounds and its preparation and use

The invention discloses an organic compound used for treating liver cancers as well as a preparation method and application thereof. The organic compound has a structural formula (III) in the specification. The chemical name of the organic compound is monochloro-thiophene-2-acetal N-phenyl thiosemicarbazide-methyl isopropylbenzene ruthenium monochloride (II). The organic compound shows good inhibitory activities towards gastric cancer SGC7901 cell lines and liver cancer BEL-7404 cell lines, can be used for preparing medicines for treating cancers, and can be used after being prepared into the forms, such as injections, tablets, pills, capsules, suspending agents or emulsion. The preparation method of the organic compound used for treating liver cancers is simple, is accessible in raw materials and has the advantage of low cost.

Cd(II) complexes with two new ligands [2-thiophenecarboxaldehyde-4-phenylthiosemicarbazone and 4-methylbenzaldehyde-4-phenylthiosemicarbazone]: Synthesis, spectral characterization and thermogravimetric studies

Background: We synthesized two new organic chelating agents, such as 2-thiophene carboxaldehyde-4-phenylthiosemicarbazone (TCPTSC) and 4-methylbenzaldehyde-4-phenylthiosemicarbazone (MBP TSC) and applied to chelation with Cd(II). Both the ligands (TCPTSC

Synthesis and evaluation of fluorimetric and colorimetric chemosensors for anions based on (oligo)thienyl-thiosemicarbazones

A family of heterocyclic thiosemicarbazone dyes (3a-d) containing thienyl groups has been synthesized, characterized, and their chromo-fluorogenic response in acetonitrile in the presence of selected anions was studied. Acetonitrile solutions of 3a-d show

Novel platinum(II) and palladium(II) complexes of thiosemicarbazones derived from 5-substitutedthiophene-2-carboxaldehydes and their antiviral and cytotoxic activities

A series of thiosemicarbazones and their platinum(II) and palladium(II) complexes have been synthesized. The chemical structures of ligands and their complexes were characterized by UV-Vis, IR, 1H NMR, 13C NMR, MS spectra, elemental analysis and TGA. The antiviral and cytotoxic activities of all compounds have been tested. Results of broad antiviral evaluation showed that none of the compounds evaluated endowed with anti-DNA or -RNA virus activity at subtoxic concentrations except for the palladium complex 1b. This compound exhibited slightly selective inhibition against cytomegalovirus. The platinum complex 4a exhibited the best cytostatic activities against human cervix carcinoma. Ligands 2, 4 and 5 showed cytostatic potential. The palladium complexes were in general less cytostatic than the corresponding platinum complexes or unliganded congeners.

Synthesis and Ribonucleotide reductase inhibitory activity of thiosemicarbazones

Ribonucleotide reductase (RR) is an important therapeutic target for anticancer drugs. The structure of human RR features a 1:1 complex of two homodimeric subunits, hRRM1 and hRRM2. Prokaryotically expressed and highly purified recombinant human RR subunits, hRRM1 and hRRM2, were used for holoenzyme-based [3H]CDP reduction in vitro assay. Ten new thiosemicarbazones (7-16) were synthesized and screened for their RR inhibitory activity. Two thiosemicarbazones derived from p-hydroxy benzaldehyde (9 and 10) were found to be active but less potent than the standard, Hydroxyurea (HU). Guided by the activity of compounds 9 and 10, 11 new thiosemicarbazones (17-27) derived from p-hydroxy benzaldehyde were prepared and screened for their RR inhibitory activity. All the 11 compounds were more potent than HU.