1435-46-7

Basic information

• Product Name: 3,5-Dichlorofluorobenzene
• Synonyms: 1,3-Dichloro-5-fluorobenzene;3,5-DICHLOROFLUOROBENZENE;3,5-Dichloro-1-fluorobenzene;3,5-Dichlorofluorobenzene 99%;3,5-Dichlorofluorobenzene99%
• CAS NO: 1435-46-7
• Molecular Formula: C₆H₃Cl₂F
• Molecular Weight: 164.99
• Mol File: 1435-46-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 68 °C
• Flash Point: 54.8 °C
• Appearance: colorless to light yellow liquid
• Density: 1.37 g/cm
• Vapor Pressure: 2.55mmHg at 25°C
• Refractive Index: 1,519
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 3,5-Dichlorofluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-Dichlorofluorobenzene(1435-46-7)
• EPA Substance Registry System: 3,5-Dichlorofluorobenzene(1435-46-7)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36/37/39-37/39
• RIDADR: 1993
• HazardClass: IRRITANT
• PackingGroup: III
• Hazardous Substances Data: 1435-46-7(Hazardous Substances Data)

Usage

Chemical Properties

colorless to light yellow liqui

InChI:InChI=1/C6H3Cl2F/c7-4-1-5(8)3-6(9)2-4/h1-3H

Upstream product

• 626-43-7 3,5-Dichloroaniline 
• 591-35-5 3,5-dichlorophenol 
• 108-70-3 1,3,5-trichlorobenzene 

Downstream Products

• 263333-82-0 2-bromo-1,3-dichloro-5-fluorobenzene 
• 462-06-6 fluorobenzene 
• 681435-09-6 2,4-dichloro-6-fluorobenzaldehyde 
• 1192002-89-3 2-(2,4-dichloro-6-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 
• 1345732-63-9 3'-chloro-5'-fluoro-(1,1'-biphenyl)-3-carbonitrile 
• 1204671-47-5 (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine hydrochloride 
• 1204677-52-0 (R)-3-[(S)-(3,5-dichlorophenoxy)phenylmethyl]pyrrolidine-1-carboxylic acid t-butyl ester 

Relevant articles and documents

Continuous flow reactor for Balz-Schiemann reaction: A new procedure for the preparation of aromatic fluorides

A facile and highly efficient procedure for the preparation of aromatic fluorides by Balz-Schiemann reaction via two continuous flow reactors has been set up. The continuous diazotization reactor was run at about 25 °C with residence times of 10-20 s, and the continuous fluorodediazoniation reactor was performed with a residence time of 1 min in high yields. The reaction times can be greatly reduced by increasing temperature and thereby taking advantage of superior mass and heat transfer of a continuous flow system.

FLUORINATION OF ORGANIC COMPOUNDS

Methods for fluorinating organic compounds are described herein.

Halex reactions of aromatic compounds catalysed by 2-azaallenium, carbophosphazenium, aminophosphonium and diphosphazenium salts: A comparative study

An increasing number of biologically active compounds in the pharma and agro-chemical sector contain carbon fluorine bonds. One of the most common methods to introduce fluorine into intermediates is the well-investigated halogen-exchange reaction, in which chloro- and bromoaromatics activated towards nucleophilic substitution, react with a fluoride source to yield the corresponding fluoroarenes. In general, the reaction is supported by phase-transfer catalysts. The use of a new class of very active phase-transfer catalysts gives the possibility of substituting even halogens with weak activation giving a convenient access to interesting compounds that are not available so far and opening up new synthetic routes in Halex chemistry. Our new classes of catalysts, CNC+ (1a), PNC+ (2a) and several different approaches presented by other groups are described and experimental results discussed.