143570-86-9Relevant academic research and scientific papers
One-pot synthesis of substituted-amino triazole-glycosides
Sutcharitruk, Warapond,Sirion, Uthaiwan,Saeeng, Rungnapha
, (2019)
This work combined three classes of compounds in the same molecule “amino triazole-glycoside” and developed a convenient method for the synthesis of this type of compound via a one-pot two step reaction. Alkylation of amine derivatives with propargyl bromide to give propargylamine was performed in the first step subsequently followed by a ‘click’ reaction with various β-azido-glycosides in the presence of CuI in aqueous solution to provide β-amino triazole-glycosides. Thirty-two examples of glycosides were obtained in moderate to good yield using this one-pot procedure.
A highly efficient tandem [3 + 2] "click" cycloaddition/6-exo-cyclization strategy for the construction of triazole fused pyrazines
Roy, Biswajit,Mondal, Debashis,Hatai, Joydev,Bandyopadhyay, Subhajit
, p. 56952 - 56956 (2015/02/19)
The pharmaceutically important tetrahydro-[1,2,3]triazolopyrazine heterocyclic architecture has been synthesized via a concise tandem "click"/6-exo-dig cyclization strategy in mixed aqueous-organic media. The generality of this mild method was expanded to various amino acid based substrates. The scopes and limitations of this method are discussed in the paper.
