143585-49-3Relevant academic research and scientific papers
MgBr2-promoted enantioselectIVe aryl addition of ArTi(OiPr)3 to ketones catalyzed by a titanium(IV) catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamine
Shu, Chao-Chi,Zhou, Shuangliu,Gau, Han-Mou
, p. 98391 - 98398 (2015/12/04)
MgBr2-promoted asymmetric addition of ArTi(OiPr)3 to ketones catalyzed by a titanium catalyst of N,N′-sulfonylated (1R,2R)-cyclohexane-1,2-diamines is reported, and results showed that the chiral N,N′-sulfonylated cyclohex
Practical enantioselective synthesis of β-lactones catalyzed by aluminum bissulfonamide complexes
Kull, Thomas,Peters, Rene
, p. 1647 - 1652 (2008/02/11)
The development of an efficient and practical aluminum-bissulfonamide complex catalyzed enantioselective formation of β-lactones by [2+2] cycloaddition of ketene (generated in situ from acetyl bromide by dehydrobromination) with various α-unbranched and -
Reversal of enantioselectivity on protonation of enol(ate)s derived from 2-methyl-1-tetralone using C2-symmetric sulfonamides
Boyd, Ewan,Coumbarides, Gregory S.,Eames, Jason,Hay, Alastair,Jones, Ray V.H.,Stenson, Rachel A.,Suggate, Michael J.
, p. 9465 - 9468 (2007/10/03)
The synthesis of enantiomerically enriched (R)-2-methyl-1-tetralone 1 (64% e.e.) was achieved through protonation of its lithium enolate 3 using a C 2-symmetrical bis-sulfonamide 5d as an internal proton source. Access to the complementary (S)-enantiomer 1 (45% e.e.) can be achieved using an external quench strategy involving acetic acid as the external proton source.
Catalytic asymmetric synthesis of vicinal diamine derivatives through enantioselective N-allylation using chiral π-allyl Pd-catalyst
Kitagawa, Osamu,Yotsumoto, Kanako,Kohriyama, Mitsuteru,Dobashi, Yasuo,Taguchi, Takeo
, p. 3605 - 3607 (2007/10/03)
(Chemical Equation Presented) N-Monoallylation of meso-vicinal diamine bistrisylamides using a chiral π-allyl-Pd catalyst proceeded in an enantioselective manner (up to 90% ee) to give desymmetrization products in good yields. The product was converted to the known σ-receptor agonist in short steps. In addition, the present catalytic asymmetric N-allylation was applied to kinetic resolution of racemic-diamide.
A Catalytic Enantioselective Reaction Using a C2-Symmetric Disulfonamide as a Chiral Ligand: Alkylation of Aldehydes Catalyzed by Disulfonamide-Ti(O-i-Pr)4-Dialkyl Zinc System
Takahashi, Hideyo,Kawakita, Takashi,Ohno, Masaji,Yoshioka, Masato,Kobayashi, Susumu
, p. 5691 - 5700 (2007/10/02)
Excellent enantioselective alkylation of aldehydes with dialkylzinc has been developed.This methodology is based on the concept of modifying the Lewis acid with a C2-symmetric, electron-withdrawing disulfonamide.The chiral Lewis acid catalysts used in the present study are the titanium complexes, prepared in-situ from disulfonamide and Ti(O-i-Pr)4.Key Words: Chiral disulfonamide; chiral titanium complex; enantioselective alkylation; dialkyl zinc; catalytic reaction
