1435880-63-9Relevant academic research and scientific papers
Multiple phosphate-linked nucleotide couplings via 5′ silyl ether protection in the phosphite triester and phosphoramidite approaches
Bare, Grant A.L.,Sherman, John C.
supporting information, p. 3207 - 3209 (2013/06/27)
Phosphite triester and phosphoramidite coupling methodologies are described for performing fourfold solution phase installations of standard deoxynucleotides onto a single cavitand template molecule. The methodologies here are based on 5′ silyl ether protection of the appropriate nucleoside or nucleoside phosphoramidite. Synthesis of a novel water-soluble species incorporating four covalently-linked guanine nucleotides is shown.
