51549-36-1

Usage

Uses

Used in Pharmaceutical Industry:
N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE is used as a nucleoside analogue for the development of antiviral and anticancer drugs. Its unique structure and chemical properties allow it to potentially target and inhibit the replication of viruses and cancer cells, offering new therapeutic options for patients.
Used in Biotechnology Industry:
N4-BENZOYL-5'-O-TERT-BUTYLDIMETHYLSILYL-2'-DEOXYCYTIDINE is used as a research probe in biological and biochemical studies. Its modified structure allows for the investigation of nucleic acid interactions, enzymatic activities, and other biological processes, contributing to a better understanding of molecular mechanisms and the development of novel therapeutic strategies.

Upstream product

• 18162-48-6 tert-butyldimethylsilyl chloride 
• 4836-13-9 N₄-benzoyl-2'-deoxycytidine 
• 3019-98-5 pentachlorophenyl benzoate 
• 98-88-4 benzoyl chloride 
• 951-77-9 2'-Deoxycytidine 
• 65-85-0 benzoic acid 
• 1548-84-1 pentafluorophenyl benzoate 

Downstream Products

• 116872-52-7 Methyl-phosphonic acid benzotriazol-1-yl ester (2R,3S,5R)-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-3-yl ester 
• 869563-54-2 N-{1-[(2R,4S,5R)-4-[Bis-(4-methoxy-phenyl)-phenyl-methoxy]-5-(tert-butyl-dimethyl-silanyloxymethyl)-tetrahydro-furan-2-yl]-2-oxo-1,2-dihydro-pyrimidin-4-yl}-benzamide 
• 51549-50-9 5'-O-tert-butyldimethylsilyl-3'-O,4-N-dibenzoyl-2'-deoxycytidine 
• 1209493-78-6 C₂₅H₃₃N₃O₅Si 
• 1360780-15-9 N₄-benzoyl-5'-O-tert-butyldimethylsilyl-3'-O-[(N,N-diisopropylamino)methoxyphosphino]-2'-deoxycytidine 
• 1360780-19-3 C₄₅H₅₇N₈O₁₄PSi 
• 1360780-20-6 C₃₇H₅₁N₈O₁₂PSi 
• 1360780-24-0 C₄₄H₆₇N₉O₁₃P₂Si 

Relevant academic research and scientific papers

Pyrimidine-purine and pyrimidine heterodinucleosides synthesis containing a triazole linkage

This article describes a synthetic route to generate two purine-pyrimidine and pyrimidine heterodinucleosides. Both microwave activated regioselective alkylation using hydride and copper-catalyzed-azide-alkyne-cycloaddition (CuAAC) were used in order to perform the synthesis.

Chelation-controlled regioselective alkylation of pyrimidine 2′-deoxynucleosides

Protection-deprotection steps, which are usually needed for regioselective alkylation of pyrimidine deoxynucleosides, can be avoided by choosing the appropriate solvent. The combined effects of low dielectric constant and possible sodium chelation by pyrimidine nucleosides may account for the unexpected regioselectivity observed in THF.

Synthesis of 3'-azido-3'-deoxythymidine-terminated oligonucleotide

A method of completely chemical synthesis of 3'-azido-3'- deoxythymidine-terminated oligonucleotides via 5'-H-phosphonate of AZT is described.

Synthesis and physicochemical properties of alternating α,β-oligodeoxyribonucleotides with alternating (3' → 3')- and (5' → 5')-internucleotide phosphodiester linkages

A simple and straightforward synthesis of α-2'-deoxycytidine and α-2'-deoxyadenosine derivatives 6a,b has been achieved from commercial N4-benzoyl-b-2'-deoxycytidine and N6-benzoyl-β-2'deoxyadenosine, respectively. Properly protected