1435913-72-6

Basic information

• Product Name: St-Asp-Glu-Gly-Glu-Glu-Thr-Phe-OH
• CAS NO: 1435913-72-6
• Molecular Weight: 1092.25
• Mol File: 1435913-72-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: St-Asp-Glu-Gly-Glu-Glu-Thr-Phe-OH(CAS DataBase Reference)
• NIST Chemistry Reference: St-Asp-Glu-Gly-Glu-Glu-Thr-Phe-OH(1435913-72-6)
• EPA Substance Registry System: St-Asp-Glu-Gly-Glu-Glu-Thr-Phe-OH(1435913-72-6)

Safety Data

• Hazardous Substances Data: 1435913-72-6(Hazardous Substances Data)

Upstream product

• 35661-42-8 N-(9-fluorenylmethoxycarbonyl)glycine tert-butyl ester 
• 84793-07-7 Fmoc-Glu-OtBu 
• 35661-40-6 N-Fmoc L-Phe 
• 71989-14-5 Fmoc-(tBu)Asp-OH 
• 120791-76-6 N-fluorenylmethoxycarbonyl-threonine-tert-butyl ester 
• 57-11-4 stearic acid 

Relevant articles and documents

Peptide inhibitors of the Keap1-Nrf2 protein-protein interaction with improved binding and cellular activity

Inhibitors of the Keap1-Nrf2 protein-protein interaction (PPI) have been proposed as potential anti-inflammatory and cancer chemopreventive agents. Such compounds have the potential to increase the intracellular concentrations of Nrf2 in a reversible manner and consequently increase the expression of a battery of gene products with antioxidant response elements (AREs) in their promoter region. In this manuscript we describe the development of peptide inhibitors with modified C- and N-termini and reduced overall charge. The activity of the compounds in inhibiting the PPI and in cellular assays of Nrf2 function are described. Compound 10 has potent activity (IC50 = 22 nM) in a cell-free fluorescence polarisation assay and induced the expression of Nrf2 dependent gene products in cells, suggesting that it has potential as a lead molecule for the development of peptidomimetic inhibitors. The Royal Society of Chemistry.