143601-46-1Relevant academic research and scientific papers
New pyrrole-based amino acids for the synthesis of peptidomimetic constrained scaffolds
Alongi, Maddalena,Minetto, Giacomo,Taddei, Maurizio
, p. 7069 - 7072 (2005)
A new family of pyrrole-based amino acids have been prepared through the microwave assisted Paal-Knorr reaction of 1-4 ketoesters derived from the corresponding β-ketoester with a functional homologation. The carboxylic group is located in position 3 of the pyrrole, whereas the amino group, protected with the Cbz moiety, is present on the side chain in positions 1 or 2. These compounds were used to prepare constrained oligopeptides.
A SIMPLE SYNTHETIC APPROACH TO Cbz-Phe-Ψ-(CH2)Gly-Pro-OMe AND RELATED PEPTIDE ISOSTERES
Hoffman, Robert V.,Kim, Hwa-Ok
, p. 3579 - 3582 (2007/10/02)
A new approach to ketomethylene and hydroxymethylene peptide isosteres has been developed which is simple, direct, and highly convergent.A key feature is construction of the central bond of a γ-keto ester by alkylation of a t-butyl β-keto ester with an α-bromo ester.
