143601-50-7

Upstream product

• 866563-64-6 methyl 4-oxo-6-phenyl-(5S)-5-[[(phenylmethoxy)carbonyl]amino]hexanoate 
• 521305-88-4 butyl 4-oxo-6-phenyl-(5S)-5-[[(phenylmethoxy)carbonyl]amino]hexanoate 
• 1161-13-3 N-Cbz-L-Phe 
• 59830-60-3 benzyl (1S)-(1-formyl-2-phenylethyl)carbamate 
• 292638-85-8 acrylic acid methyl ester 
• 143601-45-0 (S)-tert-butyl 4-<(benzyloxycarbonyl)amino>-3-oxo-5-phenylpentanoate 
• 882400-16-0 [(2S,3R)-3-((S)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-oxiranyl]-acetic acid methyl ester 
• 882400-17-1 (E)-(4S,5S)-5-Benzyloxycarbonylamino-4-hydroxy-6-phenyl-hex-2-enoic acid methyl ester 
• 143601-46-1 (S)-5-Benzyloxycarbonylamino-4-oxo-6-phenyl-hexanoic acid ethyl ester 

Downstream Products

• 674787-19-0 [(S)-1-((2S,4R)-4-Allyl-5-oxo-tetrahydro-furan-2-yl)-2-phenyl-ethyl]-carbamic acid benzyl ester 
• 900811-34-9 phenylmethyl [(1S)-2-phenyl-1-[(2S,4R)-tetrahydro-4-(1-hydroxy-1-methylethyl)-5-oxo-2-furanyl]ethyl]carbamate 
• 674787-30-5 7-[3-tert-butoxycarbonyl-3-(9H-fluoren-9-ylmethoxycarbonylamino)-propionylamino]-6-hydroxy-4-isobutylcarbamoyl-8-phenyl-octanoic acid tert-butyl ester 
• 674787-24-7 3-[(3R,5S)-5-((S)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-propionic acid tert-butyl ester 
• 674787-23-6 3-[(3R,5S)-5-((S)-1-Benzyloxycarbonylamino-2-phenyl-ethyl)-2-oxo-tetrahydro-furan-3-yl]-propionic acid 
• 674787-20-3 {(S)-1-[(2S,4R)-4-(3-Hydroxy-propyl)-5-oxo-tetrahydro-furan-2-yl]-2-phenyl-ethyl}-carbamic acid benzyl ester 
• 900811-36-1 (2R,4S,5S)-(1-methyl-2-ethenyl)hydroxy[(phenylmethoxy)carbonyl]amino-6-phenylhexanoic acid N-butylamide 

Relevant academic research and scientific papers

SmI2-mediated couplings of α-amino acid derivatives. Formal synthesis of (-)-pumiliotoxin 251D and (±)-epiquinamide

The coupling between cyclic and acyclic α-amino acid derivatives and methyl acrylate, mediated by samarium diiodide, is described. The method constitutes a powerful tool to construct indolizidine, quinolizidine, and piperidine systems in a straightforward two-step fashion. The formal synthesis of (-)-pumiliotoxin 251D and (±)-epiquinamide is achieved after two or three steps from these amino acid derivatives.

Formal total synthesis of the potent renin inhibitor aliskiren: Application of a SmI2-promoted acyl-like radical coupling

A formal total synthesis of the potent renin inhibitor aliskiren is disclosed exploiting an alternative coupling strategy recently developed by this laboratory for the preparation of the hydroxyethylene isostere-based class of protease inhibitors. The thi

A stereodivergent synthesis of hydroxyethylene dipeptide isostere via highly diastereoselective epoxidation

Epoxidation of δ-amino-β,γ-unsaturated ester with trifluoroperacetic acid afforded its epoxide in a highly diastereoselective manner. Subsequent stereodivergent epoxide opening reactions provided synthetic routes towards both the threo and erythro hydroxy

A SIMPLE SYNTHETIC APPROACH TO Cbz-Phe-Ψ-(CH2)Gly-Pro-OMe AND RELATED PEPTIDE ISOSTERES

A new approach to ketomethylene and hydroxymethylene peptide isosteres has been developed which is simple, direct, and highly convergent.A key feature is construction of the central bond of a γ-keto ester by alkylation of a t-butyl β-keto ester with an α-bromo ester.